Abortion and Its Effect on Risk of Preeclampsia and Transient Hypertension

Jennifer L. Eras; Audrey F. Saftlas; Elizabeth Triche; Chaur-Dong Hsu; Harvey A. Risch; Michael B. Bracken

doi:10.1097/00001648-200001000-00009

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Abortion and Its Effect on Risk of Preeclampsia and Transient Hypertension

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Abortion and Its Effect on Risk of Preeclampsia and Transient Hypertension

Jennifer L. Eras, Audrey F. Saftlas, Elizabeth Triche, Chaur-Dong Hsu, Harvey A. Risch and Michael B. Bracken

Epidemiology (Cambridge, Mass.), Vol.11(1), pp.36-43

01/01/2000

DOI: 10.1097/00001648-200001000-00009

PMID: 10615841

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Abstract

We examined the effect of abortion type, number, and gestational age on the risk of preeclampsia and transient hypertension among women who received prenatal care from 13 obstetric practices in southern Connecticut between April 1988 and December 1991 (N = 2,739). Subjects were interviewed before 16 weeks' gestation regarding reproductive history and pregnancy-related risk factors. We estimated the risk of preeclampsia (N = 44) and transient hypertension (N = 172) among nulliparous women who had had one or more abortions, with nulliparous women with no abortion as the referent group. Similar effects were seen for one spontaneous or induced abortion, when analyzed separately. A single prior abortion was associated with a decreased risk of preeclampsia [odds ratio (OR) = 0.35; 95% exact confidence interval (CI) = 0.09-1.01]. One abortion had only a small association with risk of transient hypertension (OR = 1.09, 95% exact CI = 0.68-1.72); however, a history of two or more abortions was associated with a decreased risk (OR = 0.42, 95% exact CI = 0.16-0.94). Among nulliparous women with a history of one abortion, a decreased risk of both hypertensive disorders was observed among women whose aborted pregnancy ended at ≥3 months gestation. These findings suggest that a history of abortion in nulliparous women is a protective factor against the risk of preeclampsia in the subsequent pregnancy.

Abortion

Hypertension

Induced abortion

Predisposing factors

Preeclampsia

Pregnancy

Pregnancy induced hypertension

Protective effects

Spontaneous abortion

Womens history

Details

Title: Subtitle: Abortion and Its Effect on Risk of Preeclampsia and Transient Hypertension
Creators: Jennifer L. Eras - Yale University
Audrey F. Saftlas
Elizabeth Triche
Chaur-Dong Hsu
Harvey A. Risch
Michael B. Bracken
Resource Type: Journal article
Publication Details: Epidemiology (Cambridge, Mass.), Vol.11(1), pp.36-43
DOI: 10.1097/00001648-200001000-00009
PMID: 10615841
NLM abbreviation: Epidemiology
ISSN: 1044-3983
eISSN: 1531-5487
Publisher: Lippincott Williams & Wilkins
Language: English
Date published: 01/01/2000
Academic Unit: Epidemiology
Record Identifier: 9984363590402771

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