About PAR: the distinct evolutionary dynamics of the pseudoautosomal region

Sarah P Otto; John R Pannell; Catherine L Peichel; Tia-Lynn Ashman; Deborah Charlesworth; Adam K Chippindale; Lynda F Delph; Rafael F Guerrero; Samuel V Scarpino; Bryant F McAllister

doi:10.1016/j.tig.2011.05.001

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About PAR: the distinct evolutionary dynamics of the pseudoautosomal region

Journal article

Open access

Peer reviewed

About PAR: the distinct evolutionary dynamics of the pseudoautosomal region

Sarah P Otto, John R Pannell, Catherine L Peichel, Tia-Lynn Ashman, Deborah Charlesworth, Adam K Chippindale, Lynda F Delph, Rafael F Guerrero, Samuel V Scarpino and Bryant F McAllister

Trends in genetics, Vol.27(9), pp.358-367

09/2011

DOI: 10.1016/j.tig.2011.05.001

PMID: 21962971

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Abstract

Sex chromosomes differ from other chromosomes in the striking divergence they often show in size, structure, and gene content. Not only do they possess genes controlling sex determination that are restricted to either the X or Y (or Z or W) chromosomes, but in many taxa they also include recombining regions. In these 'pseudoautosomal regions' (PARs), sequence homology is maintained by meiotic pairing and exchange in the heterogametic sex. PARs are unique genomic regions, exhibiting some features of autosomes, but they are also influenced by their partial sex linkage. Here we review the distribution and structure of PARs among animals and plants, the theoretical predictions concerning their evolutionary dynamics, the reasons for their persistence, and the diversity and content of genes that reside within them. It is now clear that the evolution of the PAR differs in important ways from that of genes in either the non-recombining regions of sex chromosomes or the autosomes.

Genetic Variation

Algorithms

Animals

Recombination, Genetic

Humans

Sex Chromosomes - genetics

Chromosome Mapping

Models, Genetic

Genetic Loci

Sex Characteristics

Evolution, Molecular

Details

Title: Subtitle: About PAR: the distinct evolutionary dynamics of the pseudoautosomal region
Creators: Sarah P Otto - Department of Zoology, 6270 University Boulevard, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
John R Pannell
Catherine L Peichel
Tia-Lynn Ashman
Deborah Charlesworth
Adam K Chippindale
Lynda F Delph
Rafael F Guerrero
Samuel V Scarpino
Bryant F McAllister
Resource Type: Journal article
Publication Details: Trends in genetics, Vol.27(9), pp.358-367
DOI: 10.1016/j.tig.2011.05.001
PMID: 21962971
NLM abbreviation: Trends Genet
ISSN: 0168-9525
Publisher: England
Grant note: BB/E020909/1 / Biotechnology and Biological Sciences Research Council
Language: English
Date published: 09/2011
Academic Unit: Biology
Record Identifier: 9983991960802771

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