Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish

R A Philibert; D Cheung; N Welsh; P Damschroder-Williams; B Thiel; E I Ginns; H K Gershenfeld

doi:10.1002/ajmg.1322

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Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish

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Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish

R A Philibert, D Cheung, N Welsh, P Damschroder-Williams, B Thiel, E I Ginns and H K Gershenfeld

American journal of medical genetics, Vol.105(3), pp.291-294

04/08/2001

DOI: 10.1002/ajmg.1322

PMID: 11353452

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Abstract

Previous studies provide evidence for a genetic component for susceptibility to bipolar affective disorder (BPAD) in the old-order Amish population. El-Mallakh and Wyatt [1995: Biol Psychiatry 37:235-244] have suggested that the Na(+),K(+)-ATPase may be a candidate gene for BPAD. This study examines the relationship between BPAD in the old-order Amish cohort and the Na(+),K(+)-ATPase alpha1 and beta3 subunit genes (ATP1A3, ATP1B3). A total of 166 sibling pairs were analyzed for linkage via nonparametric methods. Suggestive levels of statistical significance were not reached in any stratification model for affective illness. Overall, the results do not support linkage of bipolar disorder to the Na(+),K(+)-ATPase alpha subunit gene (ATP1A3) and beta subunit gene (ATP1B3) in these old-order Amish families and they show that these Na(+),K(+)-ATPase subunit genes are not major effect genes (>or=fourfold increased genetic risk of disease) for BPAD in the old-order Amish pedigrees. We cannot exclude other genetic variants of the Na(+),K(+)-ATPase hypothesis for BPAD, whereby other loci may modifying Na(+),K(+)-ATPase activity.

Bipolar Disorder - ethnology

Protein Subunits

Genetic Predisposition to Disease

Sodium-Potassium-Exchanging ATPase - genetics

Humans

Nuclear Family

Genotype

Bipolar Disorder - genetics

Case-Control Studies

Ethnic Groups - genetics

Statistics, Nonparametric

Bipolar Disorder - epidemiology

Cohort Studies

Genetic Linkage

Details

Title: Subtitle: Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish
Creators: R A Philibert - Department of Psychiatry, University of College of Medicine, Iowa City, Iowa, USA
D Cheung
N Welsh
P Damschroder-Williams
B Thiel
E I Ginns
H K Gershenfeld
Resource Type: Journal article
Publication Details: American journal of medical genetics, Vol.105(3), pp.291-294
DOI: 10.1002/ajmg.1322
PMID: 11353452
NLM abbreviation: Am J Med Genet
ISSN: 0148-7299
eISSN: 1096-8628
Publisher: United States
Grant note: R01-MH58882 / NIMH NIH HHS 1 P41 RR03655 / NCRR NIH HHS
Language: English
Date published: 04/08/2001
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9984003939002771

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