Journal article
Absence of amiloride-sensitive sodium absorption in the airway of an infant with pseudohypoaldosteronism
The Journal of pediatrics, Vol.135(6), pp.786-789
1999
DOI: 10.1016/S0022-3476(99)70105-8
PMID: 10586189
Abstract
We report the measurement of transepithelial voltage across the nasal epithelium in a neonate with pseudohypoaldosteronism (PHA) type 1. A 5-day-old infant was seen with hyponatremia, hyperkalemia, and elevated plasma renin and aldosterone levels. Sweat Cl
- concentration was also increased. Measurements of voltage showed a basal value of zero and the absence of an amiloride-sensitive voltage. However, voltage changed as expected for normal cyclic adenosine monophosphate–stimulated Cl
- transport. These data demonstrate the absence of amiloride-sensitive Na
+ transport across airway epithelia in a neonate with PHA. The findings suggest that measurements of voltage could be of value in the diagnosis of PHA. (J Pediatr 1999;135:786-9)
Details
- Title: Subtitle
- Absence of amiloride-sensitive sodium absorption in the airway of an infant with pseudohypoaldosteronism
- Creators
- Lawrence S PrinceJanice L LaunspachDavid S GellerRichard P LiftonJ.Howard PrattJoseph ZabnerMichael J Welsh
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.135(6), pp.786-789
- Publisher
- Mosby, Inc
- DOI
- 10.1016/S0022-3476(99)70105-8
- PMID
- 10586189
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Language
- English
- Date published
- 1999
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020776702771
Metrics
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