Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1

Gareth R Howell; Richard T Libby; Jeffrey K Marchant; Lawriston A Wilson; Ioan M Cosma; Richard S Smith; Michael G Anderson; Simon WM John

doi:10.1186/1471-2156-8-45

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Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1

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Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1

Gareth R Howell, Richard T Libby, Jeffrey K Marchant, Lawriston A Wilson, Ioan M Cosma, Richard S Smith, Michael G Anderson and Simon WM John

BMC genetics, Vol.8(1), pp.45-45

2007

DOI: 10.1186/1471-2156-8-45

PMCID: PMC1937007

PMID: 17608931

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Abstract

Background: The glaucomas are a common but incompletely understood group of diseases. DBA/2J mice develop a pigment liberating iris disease that ultimately causes elevated intraocular pressure (IOP) and glaucoma. We have shown previously that mutations in two genes, Gpnmb and Tyrp1, initiate the iris disease. However, mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear. Results: Here we present new mouse strains with Gpnmb and/or Tyrp1 genes of normal function and with a DBA/2J genetic background. These strains do not develop elevated IOP or glaucoma with age. Conclusion: These strains provide much needed controls for studying pathogenic mechanisms of glaucoma using DBA/2J mice. Given the involvement of Gpnmb and/or Tyrp1 in areas such as immunology and tumor development and progression, these strains are also important in other research fields.

Details

Title: Subtitle: Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1
Creators: Gareth R Howell - The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA
Richard T Libby - The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA
Jeffrey K Marchant - Department of Anatomy and Cell Biology, Tufts University of Medicine, Boston, MA, USA
Lawriston A Wilson - The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA
Ioan M Cosma - The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA
Richard S Smith - The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA
Michael G Anderson - Department of Physiology and Biophysics, The University of Iowa, Iowa City, IA, USA
Simon WM John - The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA
Resource Type: Journal article
Publication Details: BMC genetics, Vol.8(1), pp.45-45
Publisher: BioMed Central; London
DOI: 10.1186/1471-2156-8-45
PMID: 17608931
PMCID: PMC1937007
ISSN: 1471-2156
eISSN: 1471-2156
Language: English
Date published: 2007
Academic Unit: Molecular Physiology and Biophysics; Ophthalmology and Visual Sciences
Record Identifier: 9984025594102771

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