Journal article
Absence of manganese superoxide dismutase delays p53-induced tumor formation
Redox biology, Vol.2(1), pp.220-223
01/13/2014
DOI: 10.1016/j.redox.2014.01.001
PMCID: PMC3909777
PMID: 24494196
Abstract
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The free radical theory of cancer postulates that loss of MnSOD promotes cancer.
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We created mouse models of malignancy with and without conditional loss of MnSOD.
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We show that MnSOD loss delays the onset of p53-dependent tumor development.
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Our data suggest that inhibition of MnSOD in tumor cells may slow tumor progression.
Details
- Title: Subtitle
- Absence of manganese superoxide dismutase delays p53-induced tumor formation
- Creators
- Adam J Case - Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USAFrederick E Domann - Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Redox biology, Vol.2(1), pp.220-223
- DOI
- 10.1016/j.redox.2014.01.001
- PMID
- 24494196
- PMCID
- PMC3909777
- NLM abbreviation
- Redox Biol
- ISSN
- 2213-2317
- eISSN
- 2213-2317
- Publisher
- Elsevier
- Grant note
- name: NIH R01, award: CA114538
- Language
- English
- Date published
- 01/13/2014
- Academic Unit
- Pathology; Surgery; Radiation Oncology
- Record Identifier
- 9984047789602771
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