Journal article
Absence of selective deep white matter ischemia in chronic carotid disease : A positron emission tomographic study of regional oxygen extraction
American journal of neuroradiology : AJNR, Vol.21(4), pp.631-638
2000
PMID: 10782770
Abstract
BACKGROUND AND PURPOSE: Deep white matter may be the location of an internal arterial border zone. The purpose of this study was to determine whether the deep white matter was subject to a greater degree of ischemia than was the cortex among patients with chronic carotid occlusion. METHODS: Thirty-six patients with carotid occlusion and structurally normal deep white matter were studied with positron emission tomography. Measurements of oxygen extraction fraction were made in superficial (cortical and subcortical) regions in the middle cerebral artery territory and in deep white matter (internal border zone) regions. The presence of selective ischemia of the deep white matter was assessed by the ratio of deep white matter:superficial oxygen extraction fraction. Ipsilateral hemispheric ratios among patients were assessed as a group as compared with contralateral hemispheric ratios and as compared with normal hemispheric ratios from 15 control volunteers. RESULTS: Mean deep white matter to superficial oxygen extraction fraction ratios (±95% confidence limits) were 0.99 (±0.07), 1.01 (±0.06), and 1.02 (±0.08) for ipsilateral, contralateral, and normal hemispheres, respectively. No statistically significant difference was found between ipsilateral and contralateral (P = .691) or normal hemispheres (P = .68), nor was any statistically significant difference found when the analysis was limited to patients with increased superficial oxygen extraction fraction (n = 9). Individual deep white matter:superficial ratios were within the normal range for all patients. CONCLUSION: Normal deep white matter among patients with carotid occlusion is not subject to a greater degree of ischemia than is the overlying cortex. It is unlikely that deep white matter infarctions observed among patients with carotid occlusion are owing to chronic selective hemodynamic compromise occurring at an internal arterial border zone.
Details
- Title: Subtitle
- Absence of selective deep white matter ischemia in chronic carotid disease : A positron emission tomographic study of regional oxygen extraction
- Creators
- C. P DERDEYN - Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United StatesN. R SIMMONS - Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United StatesT. O VIDEEN - Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United StatesK. D YUNDT - Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United StatesS. M FRITSCH - Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United StatesD. L CARPENTER - Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United StatesR. L GRUBB - Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United StatesW. J POWERS - Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States
- Resource Type
- Journal article
- Publication Details
- American journal of neuroradiology : AJNR, Vol.21(4), pp.631-638
- Publisher
- American Society of Neuroradiology; Oak Brook, IL
- PMID
- 10782770
- ISSN
- 0195-6108
- eISSN
- 1936-959X
- Language
- English
- Date published
- 2000
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020848602771
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