Journal article
Absorbed dose distributions from beta-decaying radionuclides: Experimental validation of Monte Carlo tools for radiopharmaceutical dosimetry
Medical physics (Lancaster), Vol.47(11), pp.5779-5790
11/2020
DOI: 10.1002/mp.14463
PMID: 32955755
Abstract
This study aims to experimentally validate the Monte Carlo generated absorbed doses from the beta particles emitted by
Y and
Lu using radiochromic EBT3 film-based dosimetry.
Line sources of
Y and
Lu were inserted longitudinally through blocks of low-density polyethylene and tissue-equivalent slabs of cortical bone and lung equivalent plastics. Radiochromic film (Gafchromic EBT3) was laser cut to accommodate orthogonal line sources of radioactivity, and the film was sandwiched intimately between the rectangular blocks to achieve charged particle equilibrium. Line sources consisted of plastic capillary tube of length (13 ± 0.1) cm, with 0.42-mm inner diameter and a wall thickness of 0.21 mm.
Y line sources were prepared from a solution of dissolved
Y resin microspheres.
Lu line sources were prepared from an aliquot of
Lu-DOTATATE. Film exposures were conducted for durations ranging from 10 min to 38 h. Radiochromic film calibration was performed by irradiation with 6-MV-bremsstrahlung x rays from a calibrated linear accelerator, in accordance with literature recommendations. Experimental geometries were precisely simulated within the GATE Monte Carlo toolkit, which has previously been used for the generation of dose point kernels.
The mean percentage difference between measured and simulated absorbed doses were 5.04% and 7.21% for
Y and
Lu beta absorbed dose in the range of (0.1-10) Gy. Additionally, 1D gamma analysis using a local 10%/1 mm gamma criterion was performed to compare the absorbed dose distributions. The percentage of measurement points passing the gamma criterion, averaged over all tests, was 93.5%.
We report the experimental validation of Monte Carlo derived beta absorbed dose distributions for
Y and
Lu, solidifying the validity of using Monte Carlo-based methods for estimating absorbed dose from beta emitters. Overall, excellent agreement was observed between the experimental beta absorbed doses in the linear region of the radiochromic film and the GATE Monte Carlo simulations demonstrating that radiochromic film dosimetry has sufficient sensitivity and spatial resolution to be used as a tool for measuring beta decay absorbed dose distributions.
Details
- Title: Subtitle
- Absorbed dose distributions from beta-decaying radionuclides: Experimental validation of Monte Carlo tools for radiopharmaceutical dosimetry
- Creators
- Ashok Tiwari - University of IowaJohn Sunderland - University of IowaStephen A Graves - University of IowaSarah Strand - University of Iowa Hospitals and ClinicsRyan Flynn - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Medical physics (Lancaster), Vol.47(11), pp.5779-5790
- DOI
- 10.1002/mp.14463
- PMID
- 32955755
- ISSN
- 0094-2405
- eISSN
- 2473-4209
- Language
- English
- Date published
- 11/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984312986502771
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