Journal article
Abundant human β-defensin-1 expression in milk and mammary gland epithelium
The Journal of pediatrics, Vol.138(1), pp.109-112
2001
DOI: 10.1067/mpd.2001.109375
PMID: 11148522
Abstract
Human beta-defensin-1 (HBD-1) was detected in breast milk in concentrations of approximately 1 to 10 microg/mL. Breast tissue during lactation showed HBD-1 expression in mammary gland epithelia and within luminal secretions. The peptide demonstrated antimicrobial activity against Escherichia coli. HBD-1 may augment neonatal host defenses through antimicrobial effects or prime the adaptive immune system at mucosal surfaces.
Details
- Title: Subtitle
- Abundant human β-defensin-1 expression in milk and mammary gland epithelium
- Creators
- HONG PENG JIA - Department of Veterinary Pathology, Iowa State University, Ames, Iowa, United StatesTimothy STARNER - Department of Veterinary Pathology, Iowa State University, Ames, Iowa, United StatesMark ACKERMANN - Department of Veterinary Pathology, Iowa State University, Ames, Iowa, United StatesPatricia KIRBY - Department of Veterinary Pathology, Iowa State University, Ames, Iowa, United StatesBrian F TACK - Department of Veterinary Pathology, Iowa State University, Ames, Iowa, United StatesPaul B MCCRAY - Department of Veterinary Pathology, Iowa State University, Ames, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.138(1), pp.109-112
- Publisher
- Elsevier
- DOI
- 10.1067/mpd.2001.109375
- PMID
- 11148522
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Language
- English
- Date published
- 2001
- Academic Unit
- Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Pathology; Internal Medicine
- Record Identifier
- 9984093497202771
Metrics
33 Record Views