Journal article
Acamprosate
Expert Opinion on Drug Metabolism & Toxicology, Vol.6(3), pp.363-380
03/01/2010
DOI: 10.1517/17425251003641975
PMID: 20163323
Abstract
Importance of the field: Alcohol abuse and dependence are major causes of morbidity and mortality and come with a high societal cost. The illness is notoriously difficult to treat and relapse is a common occurrence. Acamprosate represents an effective addition to the treatment options available for alcohol dependence with a novel mechanism of action.
Areas covered in this review: We review the published acamprosate literature focusing on major and recent comparative clinical trials and meta-analyses. We included all studies found in National Library of Medicine's PubMed database searching on Mesh term: acamprosate excluded animal studies excluding non-English publications, and focusing on efficacy/effectiveness studies. Additionally, we discuss background information on alcohol dependence and acamprosate's putative mechanism of action. Safety and tolerability data are also presented.
What the reader will gain: The reader will gain a better understanding of the role of acamprosate in the treatment of alcohol dependence and find a useful synopsis of the more recently published literature evaluating acamprosate's effectiveness based on what are not always identically defined primary study outcomes.
Take home message: Acamprosate is safe and effective in the maintenance of abstinence from alcohol use/abuse and is most commonly used in combination with nonpharmacologic therapeutic modalities. The effect size ranged from 1.3 to 2 for most of the studies included in this review.
Details
- Title: Subtitle
- Acamprosate
- Creators
- William Klugh KennedyMegan LelouxEric C KutscherPaul L PriceAnne E MorstadRyan M Carnahan
- Resource Type
- Journal article
- Publication Details
- Expert Opinion on Drug Metabolism & Toxicology, Vol.6(3), pp.363-380
- DOI
- 10.1517/17425251003641975
- PMID
- 20163323
- NLM abbreviation
- Expert Opin Drug Metab Toxicol
- ISSN
- 1742-5255
- eISSN
- 1744-7607
- Publisher
- Taylor & Francis
- Language
- English
- Date published
- 03/01/2010
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9983995124002771
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