Journal article
Accelerated CD8 + T-cell memory and prime-boost response after dendritic-cell vaccination
Nature medicine, Vol.11(7), pp.748-756
07/2005
DOI: 10.1038/nm1257
PMID: 15951824
Abstract
Efficient boosting of memory T-cell numbers to protective levels generally requires a relatively long interval between immunizations. Decreasing this interval could be crucial in biodefense and cancer immunotherapy, in which rapid protective responses are essential. Here, we show that vaccination with peptide-coated dendritic cells (DCs) generated CD8+ T cells with the phenotype and function of memory cells within 4-6 d. These early memory CD8+ T cells underwent vigorous secondary expansion in response to a variety of booster immunizations, leading to elevated numbers of effector and memory T cells and enhanced protective immunity. Coinjection of CpG oligodeoxynucleotides, potent inducers of inflammation that did not alter the duration of DC antigen display, prevented the rapid generation of memory T cells in wild-type mice but not in mice lacking the interferon (IFN)-gamma receptor. These data show that DC vaccination stimulates a pathway of accelerated generation of memory T cells, and suggest that events of inflammation, including the action of IFN-gamma on the responding T cells, control the rate of development of memory CD8+ T cells.
Details
- Title: Subtitle
- Accelerated CD8 + T-cell memory and prime-boost response after dendritic-cell vaccination
- Creators
- Jodie S Haring - Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Road, University of IowaJohn T Harty - Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Road, University of Iowa Interdisciplinary Graduate Program in Immunology, University of Iowa, 1190 Medical LaboratoriesKelly A N Messingham - Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Road, University of IowaAli Jabbari - Interdisciplinary Graduate Program in Immunology, University of Iowa, 1190 Medical LaboratoriesVladimir P Badovinac - Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Road, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Nature medicine, Vol.11(7), pp.748-756
- DOI
- 10.1038/nm1257
- PMID
- 15951824
- ISSN
- 1078-8956
- eISSN
- 1546-170X
- Language
- English
- Date published
- 07/2005
- Academic Unit
- Dermatology; Microbiology and Immunology; Pathology
- Record Identifier
- 9984025475902771
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