Journal article
Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection
Immunity (Cambridge, Mass.), Vol.18(2), pp.265-277
02/2003
DOI: 10.1016/S1074-7613(03)00023-2
PMID: 12594953
Abstract
Respiratory dendritic cells (RDC) are believed to play a central role in the induction of adaptive immune responses to pulmonary infection. Herein we examine the basal migration of RDC from the lungs to secondary lymphoid tissues and their enhanced maturation/migration after pulmonary infection/inflammation. We demonstrate that the accelerated migration of RDC to the draining peribronchial lymph nodes occurs only during the first 24 hr after pulmonary virus infection. RDC are refractory to further migration thereafter in spite of ongoing virus replication and pulmonary inflammation. We further demonstrate that induction of this RDC refractory state suppresses additional RDC mobilization to subsequent pulmonary virus infection and results in concomitant suppression of an antiviral pulmonary CD8(+) T cell response.
Details
- Title: Subtitle
- Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection
- Creators
- Kevin L Legge - Carter Immunology Center, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USAThomas J Braciale
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.18(2), pp.265-277
- Publisher
- United States
- DOI
- 10.1016/S1074-7613(03)00023-2
- PMID
- 12594953
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Grant note
- AI15608 / NIAID NIH HHS HL33391 / NHLBI NIH HHS AI07496 / NIAID NIH HHS
- Language
- English
- Date published
- 02/2003
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984047676102771
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