Journal article
Accelerating Action of Quinidine on the Decay Phase of Transient Outward Current in Dissociated Hippocampal Pyramidal Neurons of Rats
Japanese journal of pharmacology, Vol.58(2), pp.185-188
1992
DOI: 10.1254/jjp.58.185
PMID: 1507524
Abstract
The effect of quinidine on the transient outward current (IA) in rat hippocampal neurons was studied. Quinidine at 1 × 10-6 M or more dose-dependently decreased the IA without affecting the current-voltage relationship. Quinidine accelerated the decay phase of the IA, suggesting the blockade of open channels. This result may have an implication on the side effects of quinidine in the central nervous system, since the IA is involved in the control of rhythmic electrical activity of the neurons.
Details
- Title: Subtitle
- Accelerating Action of Quinidine on the Decay Phase of Transient Outward Current in Dissociated Hippocampal Pyramidal Neurons of Rats
- Creators
- Yasuo Oyama - Department of Neurophysiology, Tohoku University School of MedicineNobutoshi Harata - Department of Neurophysiology, Tohoku University School of MedicineNorio Akaike - Department of Neurophysiology, Tohoku University School of Medicine
- Resource Type
- Journal article
- Publication Details
- Japanese journal of pharmacology, Vol.58(2), pp.185-188
- DOI
- 10.1254/jjp.58.185
- PMID
- 1507524
- NLM abbreviation
- Jpn J Pharmacol
- ISSN
- 0021-5198
- eISSN
- 1347-3506
- Publisher
- 公益社団法人 日本薬理学会
- Language
- English
- Date published
- 1992
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984025565002771
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