Journal article
Accelerating discovery in pain science: the Acute to Chronic Pain Signatures program
Pain (Amsterdam), Vol.166(11S), pp.S95-S98
11/2025
DOI: 10.1097/j.pain.0000000000003674
PMCID: PMC12614242
PMID: 41086337
Abstract
Chronic pain is a complex and multifaceted disease, with biological causes distributed across tissues and bodily systems and influenced by psychological and social factors. A major aim of pain research is to find better ways to measure signals associated with chronic pain and thus predict, track, and treat pain conditions. Emerging biological measures related to the metabolic, immune, and nervous systems hold promise for identifying the physiology underlying pain and developing new treatments. Developing such measures will require multimodal datasets from large samples in combination with methodological advances. The Acute to Chronic Pain Signatures (A2CPS) Program serves as a model for such an effort, and its data will provide investigational opportunities for years to come. Acute to Chronic Pain Signatures is collecting multiomics, psychosocial, functional, and neuroimaging data from 2800 individuals before and after thoracic or knee replacement surgery. In addition to evaluating the prognostic value of previously identified biomarkers for predicting the transition to chronic pain, A2CPS will use machine learning and artificial intelligence to link these multiple data types and identify multimodal biosignatures of future pain. Open sharing of large datasets like that of the A2CPS, and models derived from them, will accelerate discovery and allow researchers to model brain, metabolic, and immune relationships relevant for multiple facets of health.
Details
- Title: Subtitle
- Accelerating discovery in pain science: the Acute to Chronic Pain Signatures program
- Creators
- Tor D Wager - Dartmouth CollegeStephani P. Sutherland - Johns Hopkins UniversityMartin A. Lindquist - Johns Hopkins UniversityKathleen A. Sluka - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pain (Amsterdam), Vol.166(11S), pp.S95-S98
- DOI
- 10.1097/j.pain.0000000000003674
- PMID
- 41086337
- PMCID
- PMC12614242
- NLM abbreviation
- Pain
- ISSN
- 0304-3959
- eISSN
- 1872-6623
- Publisher
- Wolters Kluwer; PHILADELPHIA
- Grant note
- National Institutes of Health (NIH) Common FundOffice of the Director (OD)/Office of Strategic Coordination (OSC): U24NS112873, U54DA049110, U54DA049116, U54DA049115, U54DA049113, UM1NS112874, UM1NS118922
The A2CPS Consortium is funded by the National Institutes of Health (NIH) Common Fund, which is managed by the Office of the Director (OD)/Office of Strategic Coordination (OSC). Consortium components and their associated funding sources include a Clinical Coordinating Center (U24NS112873), Data Integration and Resource Center (U54DA049110), Omics Data Generation Centers (U54DA049116, U54DA049115, U54DA049113), Multisite Clinical Center 1 (MCC1) (UM1NS112874), and Multisite Clinical Center 2 (MCC2) (UM1NS118922).
- Language
- English
- Date published
- 11/2025
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9985014896902771
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