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Acceptability and effectiveness of antimicrobial stewardship implementation strategies on fluoroquinolone prescribing
Journal article   Open access   Peer reviewed

Acceptability and effectiveness of antimicrobial stewardship implementation strategies on fluoroquinolone prescribing

Katie J Suda, Gosia S Clore, Charlesnika T Evans, Heather Schacht Reisinger, Ibuola Kale, Kelly Echevarria, Stacey Hockett Sherlock, Eli N Perencevich, Matthew Bidwell Goetz and VA-CDC Practice-Based Research Network
Infection control and hospital epidemiology, Vol.42(11), pp.1361-1368
04/12/2021
DOI: 10.1017/ice.2021.10
PMCID: PMC9999290
PMID: 33843527
url
https://doi.org/10.1017/ice.2021.10View
Published (Version of record) Open Access

Abstract

ObjectiveTo assess the effectiveness and acceptability of antimicrobial stewardship-focused implementation strategies on inpatient fluoroquinolones.MethodsStewardship champions at 15 hospitals were surveyed regarding the use and acceptability of strategies to improve fluoroquinolone prescribing. Antibiotic days of therapy (DOT) per 1,000 days present (DP) for sites with and without prospective audit and feedback (PAF) and/or prior approval were compared.ResultsAmong all of the sites, 60% had PAF or prior approval implemented for fluoroquinolones. Compared to sites using neither strategy (64.2 ± 34.4 DOT/DP), fluoroquinolone prescribing rates were lower for sites that employed PAF and/or prior approval (35.5 ± 9.8; P = .03) and decreased from 2017 to 2018 (P < .001). This decrease occurred without an increase in advanced-generation cephalosporins. Total antibiotic rates were 13% lower for sites with PAF and/or prior approval, but this difference did not reach statistical significance (P = .20). Sites reporting that PAF and/or prior approval were "completely" accepted had lower fluoroquinolone rates than sites where it was "moderately" accepted (34.2 ± 5.7 vs 48.7 ± 4.5; P < .01). Sites reported that clinical pathways and/or local guidelines (93%), prior approval (93%), and order forms (80%) "would" or "may" be effective in improving fluoroquinolone use. Although most sites (73%) indicated that requiring infectious disease consults would or may be effective in improving fluoroquinolones, 87% perceived implementation to be difficult.ConclusionsPAF and prior approval implementation strategies focused on fluoroquinolones were associated with significantly lower fluoroquinolone prescribing rates and nonsignificant decreases in total antibiotic use, suggesting limited evidence for class substitution. The association of acceptability of strategies with lower rates highlights the importance of culture. These results may indicate increased acceptability of implementation strategies and/or sensitivity to FDA warnings.
 Epidemiology Medical and Health Sciences VA-CDC Practice-Based Research Network

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