Journal article
Accuracy of Doppler echocardiographic estimates of pulmonary artery pressures in a canine model of pulmonary hypertension
Journal of veterinary cardiology, Vol.17(1), pp.13-24
03/01/2015
DOI: 10.1016/j.jvc.2014.10.004
PMCID: PMC4550702
PMID: 25601540
Abstract
Objectives: To compare noninvasive estimates of pulmonary artery pressure (PAP) obtained via echocardiography (ECHO) to invasive measurements of PAP obtained during right heart catheterization (RHC) across a range of PAP. To examine the accuracy of estimating right atrial pressure via ECHO (RAP(ECHO)) compared to RAP measured by RHC (RAP(RHC)), and determine if adding RAP(ECHO) improves the accuracy of noninvasive PAP estimations.
Animals: 14 healthy female beagle dogs.
Methods: Comparison of ECHO and RHC measures of PAP, both at normal PAP and increased PAP generated by microbead embolization.
Results: Noninvasive estimates of PAP were moderately but significantly correlated (r of 0.68-0.78; p < 0.0006) with invasive measurements of PAP. Wide variance was noted for all estimations, with increased variance at higher PAP. The addition of RAP(ECHO) improved correlation and bias in all cases. RAP(RHC) was significantly correlated with RAP(ECHO) (r = 0.38; p = 0.04) as estimated by the ellipse area method. Median RAP(RHC) was significantly different between 3 subjective assessments of right atrial size (p = 0.037).
Conclusions: Spectral Doppler assessments of tricuspid and pulmonic regurgitation are imperfect methods for predicting PAP as measured by catheterization despite an overall moderate correlation between invasive and noninvasive values. Noninvasive measurements may be better utilized as part of a comprehensive assessment of PAP in canine patients. RAP(RHC) appears best estimated based on subjective assessment of RA size. Including estimated RAP(ECHO) in estimates of PAP improves the correlation and relatedness between noninvasive and invasive measures of PAP, but notable variability in accuracy of estimations persists. (C) 2014 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Accuracy of Doppler echocardiographic estimates of pulmonary artery pressures in a canine model of pulmonary hypertension
- Creators
- Lydia C. Soydan - University of Wisconsin–MadisonHeidi B. Kellihan - University of Wisconsin–MadisonMelissa L. Bates - University of Wisconsin–MadisonRebecca L. Stepien - University of Wisconsin–MadisonDaniel W. Consigny - University of Wisconsin–MadisonAlessandro Bellofiore - University of Wisconsin–MadisonChristopher J. Francois - University of Wisconsin–MadisonNaomi C. Chester - Univ Wisconsin, Dept Biomed Engn, Coll Engn, Madison, WI 53706 USA
- Resource Type
- Journal article
- Publication Details
- Journal of veterinary cardiology, Vol.17(1), pp.13-24
- DOI
- 10.1016/j.jvc.2014.10.004
- PMID
- 25601540
- PMCID
- PMC4550702
- NLM abbreviation
- J Vet Cardiol
- ISSN
- 1760-2734
- eISSN
- 1875-0834
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- R01HL105598 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Department of Radiology R01HL105598 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) American Heart Association (postdoctoral fellowship); American Heart Association
- Language
- English
- Date published
- 03/01/2015
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984259658602771
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