Journal article
Accuracy of detecting enlargement of aneurysms using different MRI modalities and measurement protocols
Journal of neurosurgery, Vol.130(2), pp.559-565
2019
DOI: 10.3171/2017.9.JNS171811
PMID: 29521585
Abstract
OBJECTIVE: Aneurysm growth is considered predictive of future rupture of intracranial aneurysms. However, howaccurately neuroradiologists can reliably detect incremental aneurysm growth using clinical MRI is still unknown. The purpose of this study was to assess the agreement rate of detecting aneurysm enlargement employing generally used MRI modalities.METHODS: Three silicone flow phantom models, each with 8 aneurysms of various sizes at different sites, were usedin this study. The aneurysm models were identical except for an incremental increase in the sizes of the 8 aneurysms, which ranged from 0.4 mm to 2 mm. The phantoms were imaged on 1.5-T and 3-T MRI units with both time-of-flight (TOF) and contrast-enhanced MR angiography. Three independent expert neuroradiologists measured the aneurysms in a blinded manner using different measurement approaches. The individual and agreement detection rates of aneurysm enlargement among the 3 experts were calculated.RESULTS: The mean detection rate of any increase in any aneurysmal dimension was 95.7%. The detection rates ofthe 3 observers (observers A, B, and C) were 98.0%, 96.6%, and 92.7%, respectively (p = 0.22). The detection rates of each MRI modality were 91.3% using 1.5-T TOF, 97.2% using 1.5-T with Gd, 95.8% using 3.0-T TOF, and 97.2% using 3.0-T with Gd (p = 0.31). On the other hand, the mean detection rate for aneurysm enlargement was 54.8%. Specifically, the detection rates of observers A, B, and C were 49.0%, 46.1%, and 66.7%, respectively (p = 0.009). As the incremental enlargement value increased, the detection rate for aneurysm enlargement increased. The use of 1.5-T Gd improved the detection rate for small incremental enlargement (e.g., 0.4–1 mm) of the aneurysm (p = 0.04). The location of the aneurysmalso affected the detection rate for aneurysm enlargement (p < 0.0001).CONCLUSIONS: The detection rate and interobserver agreement were very high for aneurysm enlargement of 0.4–2mm. The detection rate for at least 1 increase in any aneurysm dimension did not depend on the choice of MRI modality or measurement protocol. Use of Gd improved the accuracy of measurement. Aneurysm location may influence the accuracy of detecting enlargement.
Details
- Title: Subtitle
- Accuracy of detecting enlargement of aneurysms using different MRI modalities and measurement protocols
- Creators
- Daichi NakagawaYasunori NagahamaBruno A PoliceniMadhavan L RaghavanSeth I DillardAnna L SchumacherSrivats SarathyBrian J DlouhySaul WilsonLauren AllanHenry H WooJohn HustonHarry J CloftMax WintermarkJames C TornerRobert D BrownDavid M Hasan
- Resource Type
- Journal article
- Publication Details
- Journal of neurosurgery, Vol.130(2), pp.559-565
- DOI
- 10.3171/2017.9.JNS171811
- PMID
- 29521585
- NLM abbreviation
- J Neurosurg
- ISSN
- 0022-3085
- eISSN
- 1933-0693
- Language
- English
- Date published
- 2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Oral Pathology, Radiology and Medicine; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Surgery; Injury Prevention Research Center; Neurosurgery; Otolaryngology
- Record Identifier
- 9983995125902771
Metrics
24 Record Views