Accuracy of newer-generation home blood glucose meters in a Diabetes Research in Children Network (DirecNet) inpatient exercise study

Stuart A Weinzimer; Roy W Beck; H Peter Chase; Larry A Fox; Bruce A Buckingham; William V Tamborlane; Craig Kollman; Julie Coffey; Dongyuan Xing; Katrina J Ruedy; Diabetes Research in Children Network Study Group

doi:10.1089/dia.2005.7.675

Back

Accuracy of newer-generation home blood glucose meters in a Diabetes Research in Children Network (DirecNet) inpatient exercise study

Journal article

Peer reviewed

Accuracy of newer-generation home blood glucose meters in a Diabetes Research in Children Network (DirecNet) inpatient exercise study

Stuart A Weinzimer, Roy W Beck, H Peter Chase, Larry A Fox, Bruce A Buckingham, William V Tamborlane, Craig Kollman, Julie Coffey, Dongyuan Xing, Katrina J Ruedy, …

Diabetes technology & therapeutics, Vol.7(5), pp.675-680

10/2005

DOI: 10.1089/dia.2005.7.675

PMCID: PMC1351386

PMID: 16241867

Files and links (1)

url

http://doi.org/10.1089/dia.2005.7.675View

Open Access

Abstract

The objective of this study was to assess how the accuracy of the FreeStyle Flash (Abbott Diabetes Care, Alameda, CA) meter compares with that of the One Touch Ultra (Lifescan, Milpitas, CA) home glucose meter (HGM). Fifty children with type 1 diabetes (T1D), 10-17 years old, were admitted for two separate 24-h periods to assess the effect of exercise on subsequent nocturnal hypoglycemia. Resulting data were used in a preplanned analysis of the accuracy of the Ultra and FreeStyle HGMs. Glucose levels were measured throughout the day and night and every 15-20 min during a standardized exercise protocol. Reference samples were assayed in a central laboratory using a hexokinase enzymatic method. These reference glucose measurements were paired with HGM values from venous blood obtained within +/- 5 min. The median relative absolute difference was 5% for both the Ultra and FreeStyle HGMs, and the percentages of pairs meeting the International Organisation for Standardization criteria were 99% and 98%, respectively. The FreeStyle tended to read slightly higher than the reference method (median difference = +3 mg/dL; P < 0.001), and there was trend in this direction for the Ultra (median difference = +2 mg/dL, P = 0.15). Sensitivities for detection of hypoglycemia (reference < or = 60 and HGM < or = 70 mg/dL) were 96% and 100% for the Ultra and FreeStyle, respectively, and corresponding false-positive rates were both 5%. In a controlled clinical setting using venous blood samples, both the Ultra and FreeStyle meters demonstrated a high degree of accuracy compared with the laboratory reference over a broad range of glucose concentrations in children with T1D.

Hypoglycemia - diagnosis

Blood Glucose Self-Monitoring - standards

Reproducibility of Results

Blood Glucose - analysis

Humans

False Negative Reactions

Male

Diabetes Mellitus, Type 1 - blood

Sensitivity and Specificity

Adolescent

Female

Exercise - physiology

Blood Glucose Self-Monitoring - instrumentation

Child

Details

Title: Subtitle: Accuracy of newer-generation home blood glucose meters in a Diabetes Research in Children Network (DirecNet) inpatient exercise study
Creators: Stuart A Weinzimer - DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA. direcnet@jaeb.org
Roy W Beck
H Peter Chase
Larry A Fox
Bruce A Buckingham
William V Tamborlane
Craig Kollman
Julie Coffey
Dongyuan Xing
Katrina J Ruedy
Diabetes Research in Children Network Study Group
Contributors: Eva Tsalikian (Contributor) - University of Iowa, Stead Family Department of Pediatrics
Resource Type: Journal article
Publication Details: Diabetes technology & therapeutics, Vol.7(5), pp.675-680
DOI: 10.1089/dia.2005.7.675
PMID: 16241867
PMCID: PMC1351386
NLM abbreviation: Diabetes Technol Ther
ISSN: 1520-9156
eISSN: 1557-8593
Grant note: U10 HD041890 / NICHD NIH HHS RR00059 / NCRR NIH HHS HD041919 / NICHD NIH HHS U10 HD041906 / NICHD NIH HHS RR00070 / NCRR NIH HHS M01 RR000069 / NCRR NIH HHS RR00125 / NCRR NIH HHS M01 RR000070 / NCRR NIH HHS M01 RR006022 / NCRR NIH HHS HD041890 / NICHD NIH HHS U10 HD041918 / NICHD NIH HHS HD041908 / NICHD NIH HHS HD041918 / NICHD NIH HHS U10 HD041919 / NICHD NIH HHS U10 HD041915 / NICHD NIH HHS HD041906 / NICHD NIH HHS M01 RR00069 / NCRR NIH HHS M01 RR000059 / NCRR NIH HHS U10 HD041908 / NICHD NIH HHS HD041915 / NICHD NIH HHS U01 HD041890 / NICHD NIH HHS
Language: English
Date published: 10/2005
Academic Unit: Stead Family Department of Pediatrics
Record Identifier: 9984093359902771

Metrics

39 Record Views