Accuracy of the modified Continuous Glucose Monitoring System (CGMS) sensor in an outpatient setting: results from a diabetes research in children network (DirecNet) study

Michael J Tansey; Roy W Beck; Bruce A Buckingham; Nelly Mauras; Rosanna Fiallo-Scharer; Dongyuan Xing; Craig Killman; William V Tamborlane; Katrina J Ruedy; Diabetes Research in Children Network (DirecNet) Study Group

doi:10.1089/dia.2005.7.109

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Accuracy of the modified Continuous Glucose Monitoring System (CGMS) sensor in an outpatient setting: results from a diabetes research in children network (DirecNet) study

Journal article

Peer reviewed

Accuracy of the modified Continuous Glucose Monitoring System (CGMS) sensor in an outpatient setting: results from a diabetes research in children network (DirecNet) study

Michael J Tansey, Roy W Beck, Bruce A Buckingham, Nelly Mauras, Rosanna Fiallo-Scharer, Dongyuan Xing, Craig Killman, William V Tamborlane, Katrina J Ruedy and Diabetes Research in Children Network (DirecNet) Study Group

Diabetes technology & therapeutics, Vol.7(1), pp.109-114

02/2005

DOI: 10.1089/dia.2005.7.109

PMCID: PMC2254760

PMID: 15738708

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Abstract

We previously reported the results of an inpatient accuracy study in children with type 1 diabetes using the Continuous Glucose Monitoring System (CGMS, Medtronic MiniMed, Northridge, CA). During the course of that study, a new process was implemented for manufacturing the CGMS sensor. Accuracy from the resulting modified sensor used by only 14 children was significantly better than the original version [median relative absolute difference (RAD), 11% vs. 19%; P < 0.001]. Baseline data from a subsequent outpatient study provide an opportunity to further assess the accuracy of the modified sensor in a much larger sample of children with type 1 diabetes. As part of a randomized trial to assess the utility of the GlucoWatch G2 Biographer (Cygnus, Inc., Redwood City, CA), 200 children with type 1 diabetes were instructed to wear a CGMS for 48-72 h in an outpatient setting at baseline. Glucose measurements from a OneTouch UltraSmart (Lifescan, Inc., Milpitas, CA) home glucose meter were downloaded and used as reference values to calculate accuracy measures. The overall median RAD was 12%. Accuracy was better during hyperglycemia than during hypoglycemia (median RAD, 10% vs. 20%; P < 0.001) and on optimal versus non-optimal days but did not vary significantly by the number of calibrations entered. These data confirm the improved accuracy previously reported for the modified version of the CGMS sensor.

Blood Glucose Self-Monitoring - methods

Monitoring, Ambulatory - instrumentation

Reproducibility of Results

Monitoring, Ambulatory - methods

Diabetes Mellitus, Type 1 - blood

Humans

Blood Glucose - metabolism

Child

Details

Title: Subtitle: Accuracy of the modified Continuous Glucose Monitoring System (CGMS) sensor in an outpatient setting: results from a diabetes research in children network (DirecNet) study
Creators: Michael J Tansey - DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA. direcnet@jaeb.org
Roy W Beck
Bruce A Buckingham
Nelly Mauras
Rosanna Fiallo-Scharer
Dongyuan Xing
Craig Killman
William V Tamborlane
Katrina J Ruedy
Diabetes Research in Children Network (DirecNet) Study Group
Resource Type: Journal article
Publication Details: Diabetes technology & therapeutics, Vol.7(1), pp.109-114
DOI: 10.1089/dia.2005.7.109
PMID: 15738708
PMCID: PMC2254760
NLM abbreviation: Diabetes Technol Ther
ISSN: 1520-9156
eISSN: 1557-8593
Grant note: U10 HD041890 / NICHD NIH HHS U10 HD041915-01 / NICHD NIH HHS U10 HD041906 / NICHD NIH HHS U10 HD041919-01 / NICHD NIH HHS U10 HD041918-01 / NICHD NIH HHS HD041890 / NICHD NIH HHS U10 HD041918 / NICHD NIH HHS U10 HD041906-01 / NICHD NIH HHS U10 HD041919 / NICHD NIH HHS U10 HD041908-01 / NICHD NIH HHS U10 HD041915 / NICHD NIH HHS HD041919-0 / NICHD NIH HHS U01 HD041890-01 / NICHD NIH HHS U10 HD041908 / NICHD NIH HHS HD041915 / NICHD NIH HHS U01 HD041890 / NICHD NIH HHS
Language: English
Date published: 02/2005
Academic Unit: Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984093350402771

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