Journal article
Acepromazine. Effects on intraocular pressure
Archives of ophthalmology (1960), Vol.109(1), pp.119-124
01/1991
DOI: 10.1001/archopht.1991.01080010121043
PMID: 1987928
Abstract
We investigated the effects of the topical application of acepromazine maleate on the intraocular pressure (IOP) in 27 adult rhesus monkeys. The monkeys were divided into two groups: group 1 (16 monkeys) had both eyes normal, and group 2 (11 monkeys) had experimental chronic glaucoma in one eye and a normal fellow eye. One drop of 1% acepromazine maleate solution was instilled in one eye of monkeys in group 1 and in the glaucomatous eye of monkeys in group 2; the other eye served as the control. The IOP was measured before drug administration and 1, 4, 8, 24, and 32 hours after, with detailed slit-lamp examination of the anterior segment. Acepromazine produced no change in IOP in eyes in group 1, but it produced a fall in pressure in all eyes with high IOP in group 2, evident 1 hour after instillation, maximal between 4 and 8 hours, and still remaining after 32 hours. The pupil showed no change in size, but a transient ptosis was observed in the treated eye in all monkeys.
Details
- Title: Subtitle
- Acepromazine. Effects on intraocular pressure
- Creators
- S S Hayreh - Department of Ophthalmology, College of Medicine, University of Iowa, Iowa CityR H KardonDonna L McAllisterPatrick J Fleury
- Resource Type
- Journal article
- Publication Details
- Archives of ophthalmology (1960), Vol.109(1), pp.119-124
- DOI
- 10.1001/archopht.1991.01080010121043
- PMID
- 1987928
- NLM abbreviation
- Arch Ophthalmol
- ISSN
- 0003-9950
- eISSN
- 1538-3601
- Publisher
- American Medical Association; United States
- Grant note
- EY 1576 / NEI NIH HHS
- Language
- English
- Date published
- 01/1991
- Academic Unit
- Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9983979915702771
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