Journal article
Acetaminophen induced high anion gap metabolic acidosis: a potentially under-recognized consequence from a common medication
Pediatric nephrology (Berlin, West), Vol.40(1), pp.99-101
01/2025
DOI: 10.1007/s00467-024-06396-4
PMCID: PMC13380849
PMID: 38954037
Abstract
While metabolic acidosis is one of the most common complications in patients with chronic kidney disease (CKD), there are several uncommon etiologies that are challenging to diagnose. Here, we describe a patient on peritoneal dialysis who developed high anion gap metabolic acidosis secondary to acquired 5-oxoprolinemia from acetaminophen use. While CKD is a known risk factor for developing this potentially serious complication, this case further highlights how 5-oxoproline accumulation can occur, even with therapeutic dosing of acetaminophen.
Details
- Title: Subtitle
- Acetaminophen induced high anion gap metabolic acidosis: a potentially under-recognized consequence from a common medication
- Creators
- Dhruv Gaur - The University of Texas Southwestern Medical CenterMichael G. Michalopulos - The University of Texas Southwestern Medical CenterKeri A. Drake - The University of Texas Southwestern Medical CenterJyothsna Gattineni - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- Pediatric nephrology (Berlin, West), Vol.40(1), pp.99-101
- DOI
- 10.1007/s00467-024-06396-4
- PMID
- 38954037
- PMCID
- PMC13380849
- NLM abbreviation
- Pediatr Nephrol
- ISSN
- 0931-041X
- eISSN
- 1432-198X
- Publisher
- Springer Nature
- Number of pages
- 3
- Grant note
- K08DK131258 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01DK118021 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) CTSA-TPP-YR3- D-002 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Language
- English
- Electronic publication date
- 07/02/2024
- Date published
- 01/2025
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics
- Record Identifier
- 9984702821502771
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