Journal article
Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis
Clinical transplantation, Vol.38(3), pp.e15275-n/a
03/2024
DOI: 10.1111/ctr.15275
PMCID: PMC10939248
PMID: 38477134
Abstract
There is conflicting evidence on the role of acetylsalicylic acid (ASA) use in the development of cardiac allograft vasculopathy (CAV).
A nationwide prospective two-center study investigated changes in the coronary artery vasculature by highly automated 3-D optical coherence tomography (OCT) analysis at 1 month and 12 months after heart transplant (HTx). The influence of ASA use on coronary artery microvascular changes was analyzed in the overall study cohort and after propensity score matching for selected clinical CAV risk factors.
In total, 175 patients (mean age 52 ± 12 years, 79% male) were recruited. During the 1-year follow-up, both intimal and media thickness progressed, with ASA having no effect on its progression. However, detailed OCT analysis revealed that ASA use was associated with a lower increase in lipid plaque (LP) burden (p = .013), while it did not affect the other observed pathologies. Propensity score matching of 120 patients (60 patient pairs) showed similar results, with ASA use associated with lower progression of LPs (p = .002), while having no impact on layered fibrotic plaque (p = .224), calcification (p = .231), macrophage infiltration (p = .197), or the absolute coronary artery risk score (p = .277). According to Kaplan-Meier analysis, ASA use was not associated with a significant difference in survival (p = .699) CONCLUSION: This study showed a benefit of early ASA use after HTx on LP progression. However, ASA use did not have any impact on the progression of other OCT-observed pathologies or long-term survival.
Details
- Title: Subtitle
- Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis
- Creators
- Lucie Mayerova - Institute of Clinical and Experimental MedicinePeter Wohlfahrt - Institute of Clinical and Experimental MedicineMilan Sonka - University of IowaZhi Chen - University of IowaJosef Kautzner - Institute of Clinical and Experimental MedicineVojtech Melenovsky - Institute of Clinical and Experimental MedicineVladimir Karmazin - Institute of Clinical and Experimental MedicineIvan Malek - Institute of Clinical and Experimental MedicineHelena Bedanova - Centrum kardiovaskulární a transplantační chirurgieAles Tomasek - Centrum kardiovaskulární a transplantační chirurgieEva Ozabalova - Masaryk UniversityJan Krejci - Masaryk UniversityTomas Kovarnik - Charles UniversityMichal Pazdernik - Institute of Clinical and Experimental Medicine
- Resource Type
- Journal article
- Publication Details
- Clinical transplantation, Vol.38(3), pp.e15275-n/a
- DOI
- 10.1111/ctr.15275
- PMID
- 38477134
- PMCID
- PMC10939248
- NLM abbreviation
- Clin Transplant
- ISSN
- 0902-0063
- eISSN
- 1399-0012
- Grant note
- R01-EB004640 / NIH HHS R01 EB004640 / NIBIB NIH HHS R56 EB004640 / NIBIB NIH HHS
- Language
- English
- Date published
- 03/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984627203602771
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