Journal article
Achievement of Target A1C Levels With Negligible Hypoglycemia and Low Glucose Variability in Youth With Short-Term Type 1 Diabetes and Residual β-Cell Function
Diabetes care, Vol.35(4), pp.817-820
04/2012
DOI: 10.2337/dc11-2190
PMCID: PMC3308298
PMID: 22323414
Abstract
OBJECTIVE To determine exposure to hyper- and hypoglycemia using blinded continuous glucose monitoring (CGM) profiles in youth with type 1 diabetes (T1D) with residual β-cell function during the first year of insulin treatment.
RESEARCH DESIGN AND METHODS Blinded, 3–7 day CGM profiles were obtained in 16 short-term T1D patients (age 8–18 years, T1D duration 6–52 weeks) who had peak C-peptide levels ranging from 0.46 to 1.96 nmol/L during a mixed-meal tolerance test. Results in this short-term group were compared with those in 34 patients with well-controlled, longer-term T1D (duration ≥5 years), matched for age and A1C with the short-term T1D group, and with those in 26 age-matched nondiabetic individuals.
RESULTS Despite matching for A1C, and therefore similar mean sensor glucose levels in the two T1D groups, short-term T1D participants had a lower frequency of hypoglycemia (0.3 vs. 7.6%, P < 0.001), a trend toward less hyperglycemia (17 vs. 32%, P = 0.15), and a greater percentage in the target range (median 77 vs. 60%, P = 0.02). Indeed, the percentage of sensor glucose levels ≤70 mg/dL in the short-term T1D group (0.3%) did not differ from those in the nondiabetic group (1.7%, P = 0.73). The coefficient of variation of sensor glucose levels (an index of glucose variability) was lower in short-term vs. longer-term T1D participants (27 vs. 42%, respectively, P < 0.001).
CONCLUSIONS In youth with short-term T1D who retain residual β-cell function, there is negligible exposure to hypoglycemia and lower glucose variability than in youth with well-controlled T1D of longer duration.
Details
- Title: Subtitle
- Achievement of Target A1C Levels With Negligible Hypoglycemia and Low Glucose Variability in Youth With Short-Term Type 1 Diabetes and Residual β-Cell Function
- Creators
- Jennifer Sherr - Pediatric Endocrinology, Yale University, New Haven, Connecticut; theWilliam V Tamborlane - Pediatric Endocrinology, Yale University, New Haven, Connecticut; theDongyuan Xing - Jaeb Center for Health Research, Tampa, FloridaEva Tsalikian - Pediatric Endocrinology, University of Iowa, Iowa City, IowaNelly Mauras - Pediatric Endocrinology, Nemours Children’s Clinic, Jacksonville, FloridaBruce Buckingham - Pediatric Endocrinology, Stanford University, Stanford, CaliforniaNeil H White - Department of Pediatrics, Washington University in St. Louis, St. Louis, MissouriAna Maria Arbelaez - Department of Pediatrics, Washington University in St. Louis, St. Louis, MissouriRoy W Beck - Jaeb Center for Health Research, Tampa, FloridaCraig Kollman - Jaeb Center for Health Research, Tampa, FloridaKatrina Ruedy - Jaeb Center for Health Research, Tampa, FloridaDiabetes Research in Children Network (DirecNet) Study Group
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.35(4), pp.817-820
- DOI
- 10.2337/dc11-2190
- PMID
- 22323414
- PMCID
- PMC3308298
- NLM abbreviation
- Diabetes Care
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Publisher
- American Diabetes Association
- Language
- English
- Date published
- 04/2012
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093335302771
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