Journal article
Acid-sensing ion channels: A new target for pain and CNS diseases
Current opinion in drug discovery & development, Vol.12(5), pp.693-704
09/2009
PMCID: PMC3494879
PMID: 19736627
Abstract
Low pH in tissue can evoke pain in animals and humans, and is an important factor in hyperalgesia. Research has also implicated acidosis in psychiatric and neurological diseases. One emerging class of pH-detecting receptors is that of the acid-sensing ion channels (ASICs). Advances in ASIC research have improved the understanding of the role played by pH dynamics in physiological and pathophysiological processes. Increasing evidence suggests that targeting ASICs with pharmacological agents may offer an effective and novel approach for treating pain and diseases of the CNS. However, the development of pharmaceuticals that target ASICs and are suitable for clinical use remains an obstacle. This review provides an update on ASICs and their potential for therapeutic modification in pain and CNS diseases.
Details
- Title: Subtitle
- Acid-sensing ion channels: A new target for pain and CNS diseases
- Creators
- Kathleen A Sluka - Department of Veterans Affairs Medical Center, Iowa City, IA, 52242, USAOlivia C Winter - Department of Veterans Affairs Medical Center, Iowa City, IA, 52242, USAJohn A Wemmie - Department of Veterans Affairs Medical Center, Iowa City, IA, 52242, USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in drug discovery & development, Vol.12(5), pp.693-704
- PMID
- 19736627
- PMCID
- PMC3494879
- NLM abbreviation
- Curr Opin Drug Discov Devel
- ISSN
- 1367-6733
- eISSN
- 2040-3437
- Grant note
- R01 AR053509 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS R01 AR052316 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS
- Language
- English
- Date published
- 09/2009
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology; Neurosurgery
- Record Identifier
- 9984004080302771
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