Journal article
Acid-sensing ion channels: advances, questions and therapeutic opportunities
Trends in neurosciences (Regular ed.), Vol.29(10), pp.578-586
2006
DOI: 10.1016/j.tins.2006.06.014
PMID: 16891000
Abstract
Extracellular acid can have important effects on neuron function. In central and peripheral neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular protons, and recent studies suggest diverse roles for these channels in the pathophysiology of pain, ischemic stroke and psychiatric disease. ASICs have also been implicated in mechanosensation in the peripheral nervous system and in neurotransmission in the central nervous system. Here, we briefly review advances in our understanding of ASICs, their potential contributions to disease, and the possibility for their therapeutic modification.
Details
- Title: Subtitle
- Acid-sensing ion channels: advances, questions and therapeutic opportunities
- Creators
- John A Wemmie - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAMargaret P Price - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAMichael J Welsh - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Trends in neurosciences (Regular ed.), Vol.29(10), pp.578-586
- DOI
- 10.1016/j.tins.2006.06.014
- PMID
- 16891000
- NLM abbreviation
- Trends Neurosci
- ISSN
- 0166-2236
- eISSN
- 1878-108X
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2006
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute; Neurosurgery; Internal Medicine
- Record Identifier
- 9984003926702771
Metrics
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