Journal article
Acid-sensing ion channels in pain and disease
Nature reviews. Neuroscience, Vol.14(7), pp.461-471
07/2013
DOI: 10.1038/nrn3529
PMCID: PMC4307015
PMID: 23783197
Abstract
Why do neurons sense extracellular acid? In large part, this question has driven increasing investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous system for the past two decades. Significant progress has been made in understanding the structure and function of ASICs at the molecular level. Studies aimed at clarifying their physiological importance have suggested roles for ASICs in pain, neurological and psychiatric disease. This Review highlights recent findings linking these channels to physiology and disease. In addition, it discusses some of the implications for therapy and points out questions that remain unanswered.
Details
- Title: Subtitle
- Acid-sensing ion channels in pain and disease
- Creators
- John A Wemmie - Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. john-wemmie@uiowaRebecca J TaugherCollin J Kreple
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Neuroscience, Vol.14(7), pp.461-471
- DOI
- 10.1038/nrn3529
- PMID
- 23783197
- PMCID
- PMC4307015
- NLM abbreviation
- Nat Rev Neurosci
- ISSN
- 1471-0048
- eISSN
- 1471-0048
- Publisher
- England
- Grant note
- T32 NS045549 / NINDS NIH HHS R01 MH085724 / NIMH NIH HHS R01 HL113863 / NHLBI NIH HHS 1R01MH085724 01 / NIMH NIH HHS T32 GM007337 / NIGMS NIH HHS
- Language
- English
- Date published
- 07/2013
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984003416302771
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