Acoustic Hearing After Murine Cochlear Implantation: Effects of Trauma and Implant Type

Jonathan C Kopelovich; Barbara K Robinson; Hakan Soken; Kristien J Verhoeven; Jonathon R Kirk; Shawn S Goodman; Marlan R Hansen

doi:10.1177/0003489415592162

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Acoustic Hearing After Murine Cochlear Implantation: Effects of Trauma and Implant Type

Journal article

Peer reviewed

Acoustic Hearing After Murine Cochlear Implantation: Effects of Trauma and Implant Type

Jonathan C Kopelovich, Barbara K Robinson, Hakan Soken, Kristien J Verhoeven, Jonathon R Kirk, Shawn S Goodman and Marlan R Hansen

Annals of otology, rhinology & laryngology, Vol.124(12), pp.931-939

12/2015

DOI: 10.1177/0003489415592162

PMCID: PMC7607423

PMID: 26091845

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https://www.ncbi.nlm.nih.gov/pmc/articles/7607423View

Open Access

Abstract

To model the contribution of implant material and insertion trauma on loss of acoustic hearing after cochlear implantation in an appropriate animal model. Sixty-five C57Bl/6J mice underwent unilateral implantation with implant grade materials: 2 implant grade silicones and a third uncoated platinum wire. A sham surgery group was included as a control. Serial auditory brainstem response (ABR) thresholds and distortion product otoacoustic emissions (DPOAEs) were used to discern effects on hearing over 22 weeks. Histologic measurements of damage to the organ of Corti and spiral ganglion were correlated with degree of hearing loss and material type. Organ of Corti damage correlated with rate of hearing loss soon after implantation (0-2 weeks) but not subsequently (2-22 weeks). Organ of Corti damage did not depend on implant type and was present even in sham surgery subjects when hearing was severely damaged. Spiral ganglia appeared unaffected. There was no evidence of an inflammatory or toxic effect of the materials beyond the site of implant insertion. Hearing loss and cochlear damage appear to be related to insertion trauma, with minimal effect on delayed hearing loss caused by different materials. In the C57Bl/6J mouse model, the sensory epithelium appears to be the location of damage after cochlear implantation.

Mice, Inbred C57BL

Prosthesis Design

Auditory Threshold

Organ of Corti - injuries

Animals

Evoked Potentials, Auditory, Brain Stem

Time Factors

Fibrosis

Spiral Ganglion - pathology

Cochlear Implantation - adverse effects

Models, Animal

Organ of Corti - pathology

Cochlear Implants

Otoacoustic Emissions, Spontaneous

Hearing Loss, Unilateral - etiology

Details

Title: Subtitle: Acoustic Hearing After Murine Cochlear Implantation: Effects of Trauma and Implant Type
Creators: Jonathan C Kopelovich - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA Department of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, Colorado, USA
Barbara K Robinson - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA
Hakan Soken - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA Eskisehir Military Hospital, Eskisehir, Turkey
Kristien J Verhoeven - Cochlear Technology Center Europe Belgium, Mechelen, Belgium
Jonathon R Kirk - Cochlear Ltd, Research and Technology Laboratories, Centennial, Colorado, USA
Shawn S Goodman - Department of Communication Sciences and Disorders, University of Iowa, Iowa City, Iowa, USA
Marlan R Hansen - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA Department of Neurosurgery, University of Iowa, Iowa City, Iowa, USA marlan-hansen@uiowa.edu
Resource Type: Journal article
Publication Details: Annals of otology, rhinology & laryngology, Vol.124(12), pp.931-939
DOI: 10.1177/0003489415592162
PMID: 26091845
PMCID: PMC7607423
NLM abbreviation: Ann Otol Rhinol Laryngol
ISSN: 0003-4894
eISSN: 1943-572X
Publisher: United States
Grant note: T32 DC000040 / NIDCD NIH HHS P30 DC010362 / NIDCD NIH HHS
Language: English
Date published: 12/2015
Academic Unit: Communication Sciences and Disorders; Molecular Physiology and Biophysics; Neurosurgery; Otolaryngology
Record Identifier: 9984002335302771

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