Acoustic-electric interactions in the guinea pig auditory nerve: simultaneous and forward masking of the electrically evoked compound action potential

Kirill V Nourski; Paul J Abbas; Charles A Miller; Barbara K Robinson; Fuh-Cherng Jeng

doi:10.1016/j.heares.2007.07.001

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Acoustic-electric interactions in the guinea pig auditory nerve: simultaneous and forward masking of the electrically evoked compound action potential

Journal article

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Acoustic-electric interactions in the guinea pig auditory nerve: simultaneous and forward masking of the electrically evoked compound action potential

Kirill V Nourski, Paul J Abbas, Charles A Miller, Barbara K Robinson and Fuh-Cherng Jeng

Hearing research, Vol.232(1-2), pp.87-103

10/2007

DOI: 10.1016/j.heares.2007.07.001

PMCID: PMC2048988

PMID: 17723284

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Abstract

The study investigated the time course of the effects of acoustic and electric stimulation on the electrically evoked compound action potential (ECAP). Adult guinea pigs were used in acute experimental sessions. Bursts of acoustic noise and high-rate (5000 pulses/s) electric pulse trains were used as maskers. Biphasic electric pulses were used as probes. ECAPs were recorded from the auditory nerve trunk. Simultaneous masking of the ECAP with acoustic noise featured an onset effect and a decrease in the amount of masking to a steady state. It was characterized by a two-component exponential function. The amount of masking increased with masker level and decreased with probe level. Post-stimulatory ECAP recovery often featured a non-monotonic time course, described by a three-component exponent. Electric maskers produced similar post-stimulatory effects in hearing and acutely deafened subjects. Acoustic stimulation affects the ECAP in a level- and time-dependent manner. Simultaneous masking follows a time course comparable to that of adaptation to an acoustic stimulus. Refractoriness, spontaneous activity, and adaptation are suggested to play a role in ECAP recovery. Post-stimulatory changes in synchrony, possibly due to recovery of spontaneous activity and an additional hair-cell independent mechanism, are hypothesized to contribute to the observed non-monotonicity of recovery.

Adaptation, Physiological

Cochlear Nerve - physiopathology

Electric Stimulation

Guinea Pigs

Acoustic Stimulation

Deafness - physiopathology

Furosemide

Evoked Potentials, Auditory

Refractory Period, Electrophysiological

Animals

Perceptual Masking

Time Factors

Neomycin

Models, Neurological

Auditory Perception

Deafness - chemically induced

Disease Models, Animal

Details

Title: Subtitle: Acoustic-electric interactions in the guinea pig auditory nerve: simultaneous and forward masking of the electrically evoked compound action potential
Creators: Kirill V Nourski - Department of Otolaryngology--Head and Neck Surgery, The University of Iowa, Iowa City, IA 52242, USA. kirill-nourski@uiowa.edu
Paul J Abbas
Charles A Miller
Barbara K Robinson
Fuh-Cherng Jeng
Resource Type: Journal article
Publication Details: Hearing research, Vol.232(1-2), pp.87-103
DOI: 10.1016/j.heares.2007.07.001
PMID: 17723284
PMCID: PMC2048988
NLM abbreviation: Hear Res
ISSN: 0378-5955
eISSN: 1878-5891
Publisher: Netherlands
Grant note: N01 DC021005 / NIDCD NIH HHS N01-DC-2-1005 / NIDCD NIH HHS N01-DC-21005 / NIDCD NIH HHS
Language: English
Date published: 10/2007
Academic Unit: Communication Sciences and Disorders; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984040287302771

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