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Acquired Factor VII deficiency in pediatric inflammatory bowel disease: Report of three cases
Journal article   Peer reviewed

Acquired Factor VII deficiency in pediatric inflammatory bowel disease: Report of three cases

Sevim Çakar, Gülin Eren, Tuba Hilkay Karapınar, Çiğdem Ömür Ecevıt and Özlem Bekem
Arab journal of gastroenterology, Vol.24(4), pp.256-258
11/01/2023
DOI: 10.1016/j.ajg.2023.10.002
PMID: 37993374

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Abstract

Bleeding disorders can exacerbate gastrointestinal bleeding in inflammatory bowel disease (IBD) at the time of diagnosis or flares. Factor VII (FVII) deficiency is a life-threatening rare congenital bleeding disorder in childhood. This study describes three adolescent patients with IBD accompanied by acquired FVII deficiency. This is the first case series of patients with IBD accompanied by FVII deficiency. We hypothesized that inflammation, accelerated consumption, disease severity, and weight loss can cause decreased FVII activity in patients diagnosed with IBD. To control intestinal bleeding, we must keep in mind factor deficiencies in IBD.
Children Factor VII deficiency Inflammatory bowel disease

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