Journal article
Acquired Hypocalciuric Hypercalcemia in a Patient With CKD
American journal of kidney diseases, Vol.62(6), pp.1151-1154
12/2013
DOI: 10.1053/j.ajkd.2013.04.023
PMID: 23810542
Abstract
We present a case of an 82-year-old woman with elevated parathyroid hormone (PTH) levels, hypocalciuria, hypercalcemia, and stage 3 chronic kidney disease. Hypocalciuria initially was attributed to chronic kidney disease, and hypercalcemia was attributed to primary hyperparathyroidism. Subsequent laboratory studies showed autoantibodies in the patient's serum directed against the calcium-sensing receptor (CaSR). Functional testing in a CaSR-transfected human embryonic kidney–293 cell line showed that the patient's antibodies inhibited CaSR-mediated intracellular signaling that ordinarily would have been stimulated by extracellular calcium ions. Her serum calcium and PTH levels were normalized by treatment with the calcimimetic cinacalcet. We advise consideration of the presence of inhibitory autoantibodies directed at the CaSR in patients with hypercalcemic hyperparathyroidism and unexplained hypocalciuria or with confounding conditions affecting interpretation of urinary calcium measurement. A calcimimetic is an effective treatment for the hypercalcemia and elevated PTH levels in acquired hypocalciuric hypercalcemia caused by inhibitory anti-CaSR autoantibodies.
Details
- Title: Subtitle
- Acquired Hypocalciuric Hypercalcemia in a Patient With CKD
- Creators
- Elizabeth Kuo - Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TXE. Helen Kemp - Department of Human Metabolism, The Medical School, University of Sheffield, Sheffield, United KingdomHarpreet K Sandhu - Department of Human Metabolism, The Medical School, University of Sheffield, Sheffield, United KingdomEdward M Brown - Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MAAnthony P Weetman - Department of Human Metabolism, The Medical School, University of Sheffield, Sheffield, United KingdomChou-Long Huang - Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX
- Resource Type
- Journal article
- Publication Details
- American journal of kidney diseases, Vol.62(6), pp.1151-1154
- Publisher
- Elsevier Inc
- DOI
- 10.1053/j.ajkd.2013.04.023
- PMID
- 23810542
- ISSN
- 0272-6386
- eISSN
- 1523-6838
- Language
- English
- Date published
- 12/2013
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094406202771
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