Journal article
Acquired Personality Disturbances Associated With Bilateral Damage to the Ventromedial Prefrontal Region
Developmental neuropsychology, Vol.18(3), pp.355-381
12/01/2000
DOI: 10.1207/S1532694205Barrash
PMID: 11385830
Abstract
Personality changes in 7 participants with bilateral ventromedial prefrontal lesions (PF-BVM), 14 participants with prefrontal lesions but not bilateral ventromedial involvement (PF-NBVM), and 36 with nonprefrontal lesions (NPF) were investigated with the Iowa Rating Scales of Personality Change. Informants rated 30 specific characteristics for degree of disturbance and change from premorbid personality. PF-BVM participants showed a higher rate of acquired disturbances than NPF participants in blunted emotional experience, apathy, low emotional expressiveness, inappropriate affect, poor frustration tolerance, irritability, lability, indecisiveness, poor judgment, social inappropriateness, lack of planning, lack of initiation and persistence, and lack of insight. Differences between the PF-BVM and PF-NBVM groups were significant for several of these characteristics. All 7 PF-BVM participants developed a syndrome, including general dampening of emotional experience; poorly modulated emotional reactions; defective decision making, especially in the social realm; impaired goal-directed behavior; and striking lack of insight. Similarities between this syndrome of "acquired sociopathy" and developmental psychopathy in characteristic personality disturbances and psychophysiological abnormalities suggest that diminished emotionality, impaired decision making, and psychosocial dysfunction may be related to ventromedial prefrontal dysfunction in both groups.
Details
- Title: Subtitle
- Acquired Personality Disturbances Associated With Bilateral Damage to the Ventromedial Prefrontal Region
- Creators
- Joseph BarrashDaniel TranelSteven W Anderson
- Resource Type
- Journal article
- Publication Details
- Developmental neuropsychology, Vol.18(3), pp.355-381
- DOI
- 10.1207/S1532694205Barrash
- PMID
- 11385830
- NLM abbreviation
- Dev Neuropsychol
- ISSN
- 8756-5641
- eISSN
- 1532-6942
- Publisher
- Lawrence Erlbaum Associates, Inc
- Language
- English
- Date published
- 12/01/2000
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002422002771
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