Journal article
Acquired partial lipodystrophy is associated with increased risk for developing metabolic abnormalities
Metabolism, clinical and experimental, Vol.64(9), pp.1086-1095
09/01/2015
DOI: 10.1016/j.metabol.2015.06.004
PMID: 26139569
Abstract
Acquired partial lipodystrophy (APL) is a rare disorder characterized by progressive selective fat loss. In previous studies, metabolic abnormalities were reported to be relatively rare in APL, whilst they were quite common in other types of lipodystrophy syndromes.
In this nationwide cohort study, we evaluated 21 Turkish patients with APL who were enrolled in a prospective follow-up protocol. Subjects were investigated for metabolic abnormalities. Fat distribution was assessed by whole body MRI. Hepatic steatosis was evaluated by ultrasound, MRI and MR spectroscopy. Patients with diabetes underwent a mix meal stimulated C-peptide/insulin test to investigate pancreatic beta cell functions. Leptin and adiponectin levels were measured.
Fifteen individuals (71.4%) had at least one metabolic abnormality. Six patients (28.6%) had diabetes, 12 (57.1%) hypertrigylceridemia, 10 (47.6%) low HDL cholesterol, and 11 (52.4%) hepatic steatosis. Steatohepatitis was further confirmed in 2 patients with liver biopsy. Anti-GAD was negative in all APL patients with diabetes. APL patients with diabetes had lower leptin and adiponectin levels compared to patients with type 2 diabetes and healthy controls. However, contrary to what we observed in patients with congenital generalized lipodystrophy (CGL), we did not detect consistently very low leptin levels in APL patients. The mix meal test suggested that APL patients with diabetes had a significant amount of functional pancreatic beta cells, and their diabetes was apparently associated with insulin resistance.
Our results show that APL is associated with increased risk for developing metabolic abnormalities. We suggest that close long-term follow-up is required to identify and manage metabolic abnormalities in APL.
Details
- Title: Subtitle
- Acquired partial lipodystrophy is associated with increased risk for developing metabolic abnormalities
- Creators
- Baris Akinci - Dokuz Eylül UniversityFatos Dilan Koseoglu - Izmir Tepecik Eğitim ve Araştırma HastanesiHuseyin Onay - Ege UniversitySevgi Yavuz - İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma HastanesiCanan Altay - Dokuz Eylül UniversityIlgin Yildirim Simsir - Ege UniversitySecil Ozisik - Dokuz Eylül UniversityLeyla Demir - Izmir Atatürk Eğitim ve Araştırma HastanesiMeltem Korkut - Yeditepe UniversityNusret Yilmaz - Akdeniz UniversitySamim Ozen - Ege UniversityGulcin Akinci - Dr.Behcet Uz Children’s Hospital, Division of Pediatric Neurology, Izmir, TurkeyTahir Atik - Ege UniversityMehmet Calan - Dokuz Eylül UniversityMustafa Secil - Dokuz Eylül UniversityAbdurrahman Comlekci - Dokuz Eylül UniversityTevfik Demir - Dokuz Eylül University
- Resource Type
- Journal article
- Publication Details
- Metabolism, clinical and experimental, Vol.64(9), pp.1086-1095
- DOI
- 10.1016/j.metabol.2015.06.004
- PMID
- 26139569
- NLM abbreviation
- Metabolism
- ISSN
- 0026-0495
- eISSN
- 1532-8600
- Publisher
- Elsevier Inc
- Number of pages
- 10
- Language
- English
- Date published
- 09/01/2015
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9985214100302771
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