Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps

Geng Xu; Jiahong Xia; Xiaoyang Hua; Han Zhou; Chuanzhao Yu; Zheng Liu; Kemin Cai; Jianbo Shi; Huabin Li

doi:10.1186/1465-9921-10-13

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Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps

Journal article

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Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps

Geng Xu, Jiahong Xia, Xiaoyang Hua, Han Zhou, Chuanzhao Yu, Zheng Liu, Kemin Cai, Jianbo Shi and Huabin Li

Respiratory research, Vol.10(13), pp.13-13

02/27/2009

DOI: 10.1186/1465-9921-10-13

PMCID: PMC2651851

PMID: 19250527

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Abstract

Background: Decreased infiltration of Foxp3+ T regulatory cell (Treg) is considered to be critical for the Th1/Th2 dysregulation of nasal polyps, while the cellular mechanism underlying Foxp3+ Treg insufficiency is currently not well defined. Methods: We attempted to investigate the tissue expression of phosphorylated mammalian target of rapamycin (pmTOR) and infiltration of Foxp3+ Tregs in 28 nasal polyps and 16 controls by histological staining. We also evaluated the effects of blocking the mTOR signaling pathway with rapamycin on T cell phenotype selection and Foxp3+ CD4+ Tregs expansion in a tissue culture system. Results: Significantly increased infiltration of pmTOR+ inflammatory cells and decreased infiltration of Foxp3+ CD4+ Tregs into nasal polyps was observed, with an inverse association. In the tissue culture system, we detected significantly elevated Foxp3 expression and IL-10 production, as well as an increased percentage of Foxp3+ Tregs in nasal polyps after blocking the mTOR signaling pathway with rapamycin. Conclusion: Here we demonstrate for the first time that the mTOR signaling pathway is associated with Foxp3+ Tregs insufficiency in nasal polyps. Inhibition of the mTOR signaling pathway may be helpful for enhancement of Foxp3+ Treg expansion, as well as modulation of T cell phenotype imbalances in nasal polyps.

Life Sciences & Biomedicine

Respiratory System

Science & Technology

Details

Title: Subtitle: Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps
Creators: Geng Xu - Allergy and Cancer Center, Otorhinolaryngology Hospital of the First Affiliated Hospital of Sun Yat-sen University, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, PR China
Jiahong Xia - Huazhong University of Science and Technology
Xiaoyang Hua - Huazhong University of Science and Technology
Han Zhou - Nanjing Medical University
Chuanzhao Yu - Nanjing Medical University
Zheng Liu - Huazhong University of Science and Technology
Kemin Cai - Nanjing Medical University
Jianbo Shi - Allergy and Cancer Center, Otorhinolaryngology Hospital of the First Affiliated Hospital of Sun Yat-sen University, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, PR China
Huabin Li - Allergy and Cancer Center, Otorhinolaryngology Hospital of the First Affiliated Hospital of Sun Yat-sen University, Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou, PR China
Resource Type: Journal article
Publication Details: Respiratory research, Vol.10(13), pp.13-13
DOI: 10.1186/1465-9921-10-13
PMID: 19250527
PMCID: PMC2651851
NLM abbreviation: Respir Res
ISSN: 1465-993X
eISSN: 1465-993X
Publisher: Springer Nature
Number of pages: 13
Grant note: BK2007610 / Natural Science Fund of Jiangsu Province; Natural Science Foundation of Jiangsu Province 30700935; 30872845; 30872847 / National Natural Science Fund; National Natural Science Foundation of China (NSFC)
Language: English
Date published: 02/27/2009
Academic Unit: Otolaryngology
Record Identifier: 9984311439302771

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