Journal article
Activation of GABAA receptors: views from outside the synaptic cleft
Neuron (Cambridge, Mass.), Vol.56(5), pp.763-770
12/06/2007
DOI: 10.1016/j.neuron.2007.11.002
PMID: 18054854
Abstract
Some GABA(A) receptors (GABA(A)Rs) are activated by low transmitter levels present in the extracellular space and generate an uninterrupted conductance referred to as "tonic." This tonic conductance is highly sensitive to all factors regulating the amount of GABA surrounding the neurons. Only a few GABA(A)Rs with particular subunit combinations are well suited to mediate the tonic conductance. These same receptors constitute important and specific targets for various endogenous and exogenous neuroactive compounds and possible therapeutic targets.
Details
- Title: Subtitle
- Activation of GABAA receptors: views from outside the synaptic cleft
- Creators
- Joseph Glykys - Interdepartmental PhD Program for Neuroscience, The David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USAIstvan Mody
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.56(5), pp.763-770
- Publisher
- United States
- DOI
- 10.1016/j.neuron.2007.11.002
- PMID
- 18054854
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Language
- English
- Date published
- 12/06/2007
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984020500602771
Metrics
23 Record Views