Journal article
Activation of the Jak-Stat Pathway in Cells That Exhibit Selective Sensitivity to the Antiviral Effects of IFN-beta Compared with IFN-alpha
Journal of interferon & cytokine research, Vol.19(7), pp.797-801
07/1999
DOI: 10.1089/107999099313659
PMID: 10454351
Abstract
We determined whether selective activation of components of the Jak-Stat pathway by different type I interferons (IFN) occurs in human myocardial fibroblasts that exhibit much higher sensitivity to the antiviral effects of IFN-beta than of IFN-alpha. Similar levels of activation of the Tyk2 kinase and the Stat3 transcription factor were induced in response to either IFN-beta or IFN-alpha treatment. However, activation of the Jak1 tyrosine kinase was detectable only in IFN-beta-treated but not IFN-alpha-treated cells. Consistent with this, tyrosine phosphorylation of Stat1 and Stat2 and formation of the IFN-stimulated gene factor 3 (ISGF3) complex occurred to a much higher degree in response to IFN-beta stimulation. These findings demonstrate that differential activation of distinct components of the Jak-Stat pathway by different type I IFN can occur. Furthermore, they strongly suggest that such selective activation accounts for the occurrence of differences in the antiviral properties of distinct type I IFN in certain cell types.
Details
- Title: Subtitle
- Activation of the Jak-Stat Pathway in Cells That Exhibit Selective Sensitivity to the Antiviral Effects of IFN-beta Compared with IFN-alpha
- Creators
- Isabella M GrumbachEleanor N FishShahab UddinBeata MajchrzakOscar R ColamoniciHans R FigullaAlbert HeimLeonidas C Platanias
- Resource Type
- Journal article
- Publication Details
- Journal of interferon & cytokine research, Vol.19(7), pp.797-801
- DOI
- 10.1089/107999099313659
- PMID
- 10454351
- ISSN
- 1079-9907
- eISSN
- 1557-7465
- Language
- English
- Date published
- 07/1999
- Academic Unit
- Cardiovascular Medicine; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984094550702771
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