Journal article
Activation of the extracytoplasmic function cr factor crV by lysozyme in Clostridioides difficile
Current opinion in microbiology, Vol.65, pp.162-166
02/01/2022
DOI: 10.1016/j.mib.2021.11.008
PMCID: PMC8792214
PMID: 34894542
Abstract
Clostridioides difficile is naturally resistant to high levels of lysozyme an important component of the innate immune defense system. C. difficile encodes both constitutive as well as inducible lysozyme resistance genes. The inducible lysozyme resistance genes are controlled by an alternative sigma factor sigma(V) that belongs to the Extracytoplasmic function s factor family. In the absence of lysozyme, the activity of sigma(V) is inhibited by the anti-sigma factor RsiV. In the presence of lysozyme RsiV is destroyed via a proteolytic cascade that leads to sigma(V) activation and increased lysozyme resistance. This review highlights how activity of sigma(V) is controlled.
Details
- Title: Subtitle
- Activation of the extracytoplasmic function cr factor crV by lysozyme in Clostridioides difficile
- Creators
- Theresa D. Ho - University of Iowa, Microbiology and ImmunologyCraig D. Ellermeier - University of Iowa, Microbiology and Immunology
- Resource Type
- Journal article
- Publication Details
- Current opinion in microbiology, Vol.65, pp.162-166
- DOI
- 10.1016/j.mib.2021.11.008
- PMID
- 34894542
- PMCID
- PMC8792214
- NLM abbreviation
- Curr Opin Microbiol
- ISSN
- 1369-5274
- eISSN
- 1879-0364
- Publisher
- Current Biology Ltd
- Number of pages
- 5
- Grant note
- National Institute of Allergy and Infectious Disease; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Language
- English
- Date published
- 02/01/2022
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984297315202771
Metrics
21 Record Views