Journal article
Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury
Nature medicine, Vol.5(4), pp.392-398
04/1999
DOI: 10.1038/7391
PMID: 10202927
Abstract
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can cause fatal acute lung infections in critically ill individuals. Damage to the lung epithelium is associated with the expression of toxins that are directly injected into eukaryotic cells through a type Ill-mediated secretion and translocation mechanism. Here we show that the P. aeruginosa homolog of the Yersinia V antigen, PcrV, is involved in the translocation of type III toxins. Vaccination against PcrV ensured the survival of challenged mice and decreased lung inflammation and injury. Antibodies to PcrV inhibited the translocation of type III toxins.
Details
- Title: Subtitle
- Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury
- Creators
- Michael A Gropper - Department of Anesthesia and Perioperative Care, The University of California, San Francisco Department of Physiology, The University of California, San FranciscoDara W Frank - Department of Microbiology and Molecular Genetics, Medical College of WisconsinJeanine P Wiener-Kronish - Department of Anesthesia and Perioperative Care, The University of California, San Francisco Department of Medicine, The University of California, San Francisco Cardiovascular Research Institute, The University of California, San FranciscoTeiji Sawa - Department of Anesthesia and Perioperative Care, The University of California, San FranciscoKiyoyasu Kurahashi - Department of Anesthesia and Perioperative Care, The University of California, San FranciscoTimothy L Yahr - Department of Biochemistry, Dartmouth Medical SchoolMaria Ohara - Department of Anesthesia and Perioperative Care, The University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- Nature medicine, Vol.5(4), pp.392-398
- DOI
- 10.1038/7391
- PMID
- 10202927
- ISSN
- 1078-8956
- eISSN
- 1546-170X
- Language
- English
- Date published
- 04/1999
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001150802771
Metrics
33 Record Views