Activities of available and investigational antifungal agents against rhodotorula species

D J Diekema; B Petroelje; S A Messer; R J Hollis; M A Pfaller

doi:10.1128/JCM.43.1.476-478.2005

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Activities of available and investigational antifungal agents against rhodotorula species

Journal article

Open access

Peer reviewed

Activities of available and investigational antifungal agents against rhodotorula species

D J Diekema, B Petroelje, S A Messer, R J Hollis and M A Pfaller

Journal of clinical microbiology, Vol.43(1), pp.476-478

01/2005

DOI: 10.1128/JCM.43.1.476-478.2005

PMCID: PMC540164

PMID: 15635020

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Abstract

Rhodotorula species are emerging pathogens in immunocompromised patients. We report the in vitro activities of eight antifungals against 64 Rhodotorula isolates collected in surveillance programs between 1987 and 2003. Rhodotorula strains are resistant in vitro to fluconazole (MIC at which 50% of the isolates tested are inhibited [MIC(50)], >128 microg/ml) and caspofungin (MIC(50), >8 microg/ml). Amphotericin B (MIC(50),1 microg/ml) and flucytosine (MIC(50), 0.12 microg/ml) are both active in vitro, and the new and investigational triazoles all have some in vitro activity, with ravuconazole being the most active (MIC(50), 0.25 microg/ml).

Antifungal Agents - pharmacology

Microbial Sensitivity Tests

Mycoses - epidemiology

Humans

Mycoses - microbiology

Drug Resistance, Fungal

Population Surveillance

Rhodotorula - drug effects

Rhodotorula - isolation & purification

Details

Title: Subtitle: Activities of available and investigational antifungal agents against rhodotorula species
Creators: D J Diekema - Department of Internal Medicine, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. daniel-diekema@uiowa.edu
B Petroelje
S A Messer
R J Hollis
M A Pfaller
Resource Type: Journal article
Publication Details: Journal of clinical microbiology, Vol.43(1), pp.476-478
DOI: 10.1128/JCM.43.1.476-478.2005
PMID: 15635020
PMCID: PMC540164
NLM abbreviation: J Clin Microbiol
ISSN: 0095-1137
eISSN: 1098-660X
Publisher: United States
Language: English
Date published: 01/2005
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983986257202771

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