Journal article
Activity of and Resistance to Moxifloxacin in Staphylococcus aureus
Antimicrobial agents and chemotherapy, Vol.47(4), pp.1410-1415
04/2003
DOI: 10.1128/AAC.47.4.1410-1415.2003
PMCID: PMC152517
PMID: 12654680
Abstract
Moxifloxacin has enhanced potency against
Staphylococcus aureus
, lower propensity to select for resistant mutants, and higher bactericidal activity against highly resistant strains than ciprofloxacin. Despite similar activity against purified
S. aureus
topoisomerase IV and DNA gyrase, it selects for topoisomerase IV mutants, making topoisomerase IV the preferred target in vivo.
Details
- Title: Subtitle
- Activity of and Resistance to Moxifloxacin in Staphylococcus aureus
- Creators
- Dilek Ince - Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114-2696Xiamei Zhang - Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114-2696David C Hooper - Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114-2696
- Resource Type
- Journal article
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.47(4), pp.1410-1415
- DOI
- 10.1128/AAC.47.4.1410-1415.2003
- PMID
- 12654680
- PMCID
- PMC152517
- NLM abbreviation
- Antimicrob Agents Chemother
- ISSN
- 0066-4804
- eISSN
- 1098-6596
- Publisher
- American Society for Microbiology
- Language
- English
- Date published
- 04/2003
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094718302771
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