Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats

Nilda Berenice de Vargas Barbosa; Caroline Oliveira; Dioneia Araldi; Vanderlei Folmer; Joao Batista Teixeira Rocha; Cristina Wayne Nogueira

doi:10.1248/bpb.31.2200

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Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats

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Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats

Nilda Berenice de Vargas Barbosa, Caroline Oliveira, Dioneia Araldi, Vanderlei Folmer, Joao Batista Teixeira Rocha and Cristina Wayne Nogueira

Biological & pharmaceutical bulletin, Vol.31(12), pp.2200-2204

12/01/2008

DOI: 10.1248/bpb.31.2200

PMID: 19043199

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Abstract

This study was designed to evaluate the effect of diphenyl diselenide in a classical model of alloxan-induced diabetes in rats. Oxidative stress is involved in alloxan toxic effects and we have hypothesized that diphenyl diselenide via its antioxidant properties could confer protection against alloxan pancreatic toxicity. Diabetes was induced by administration of alloxan (150 mg/kg, intravenously). Diphenyl diselenide (10 mg/kg, subcutaneously) was administered for 6 d before (prevention group) or for 6 d after (remediation group) diabetes induction. Diphenyl diselenide treatment reduced the blood glucose and fructosamine levels, which were increased in alloxan-treated rats. However, the delta-aminolevulinate dehydratase (delta-ALA-D) activity inhibited by alloxan was not restored by diphenyl diselenide. Moreover, diphenyl diselenide caused by itself an inhibition in hepatic and renal delta-ALA-D activity. Our findings suggest that the acute treatment with diphenyl diselenide reduces the hyperglycemia but does not improve delta-ALA-D activity decreased by alloxan. Although the dose of diphenyl diselenide used here for treating diabetic animals has been relatively high and produced toxic effects, the compound or analogous molecules might not be rejected as a promising anti-hyperglycemic agent.

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Pharmacology & Pharmacy

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Title: Subtitle: Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats
Creators: Nilda Berenice de Vargas Barbosa - Fundacao Univ Fed Pampa, Ctr Ciencias Saude, BR-97500970 Uruguaiana, RS, Brazil
Caroline Oliveira - Universidade Federal do Pampa
Dioneia Araldi - Universidade Federal do Pampa
Vanderlei Folmer - Universidade Federal do Pampa
Joao Batista Teixeira Rocha - Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil
Cristina Wayne Nogueira - Universidade Federal de Santa Maria
Resource Type: Journal article
Publication Details: Biological & pharmaceutical bulletin, Vol.31(12), pp.2200-2204
DOI: 10.1248/bpb.31.2200
PMID: 19043199
NLM abbreviation: Biol Pharm Bull
ISSN: 0918-6158
eISSN: 1347-5215
Publisher: Pharmaceutical Soc Japan
Number of pages: 5
Grant note: FAPERGS; Fundacao de Amparo a Ciencia e Tecnologia do Estado do Rio Grande do Sul (FAPERGS) FINEP; Financiadora de Inovacao e Pesquisa (Finep) CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) CAPES; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Language: English
Date published: 12/01/2008
Academic Unit: Neuroscience and Pharmacology
Record Identifier: 9985177939502771

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