Acute Effects of a Mixed Meal on Arterial Stiffness and Central Hemodynamics in Healthy Adults

Jennifer L Taylor; Timothy B Curry; Luke J Matzek; Michael J Joyner; Darren P Casey

doi:10.1093/ajh/hpt211

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Acute Effects of a Mixed Meal on Arterial Stiffness and Central Hemodynamics in Healthy Adults

Journal article

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Acute Effects of a Mixed Meal on Arterial Stiffness and Central Hemodynamics in Healthy Adults

Jennifer L Taylor, Timothy B Curry, Luke J Matzek, Michael J Joyner and Darren P Casey

American journal of hypertension, Vol.27(3), pp.331-337

03/2014

DOI: 10.1093/ajh/hpt211

PMCID: PMC3915744

PMID: 24242825

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Abstract

BACKGROUND Elevated central pressures and arterial stiffness are associated with increased peripheral resistance and higher sympathetic nervous system activity. Additionally, consumption of a meal is known to be sympathoexcitatory. However, the acute effects of a meal on aortic wave reflection and stiffness are unknown. Therefore, we tested the hypothesis that aortic wave reflection and stiffness would increase after a meal. METHODS We examined these effects using high-fidelity radial arterial pressure waveforms and carotid-femoral pulse wave velocity measured noninvasively by applanation tonometry before and 60 and 180 minutes after ingestion of a liquid mixed meal (Ensure; 40% of daily energy expenditure) in 17 healthy adults (9 men/8 women; aged 29±2 years). Additionally, we measured sympathetic activity by microneurography at baseline and up to 60 minutes after the meal. RESULTS Although sympathetic activity increased after the meal, both peripheral and central pressures were reduced at 180 minutes from baseline (all P < 0.05). Contrary to our hypothesis, augmentation index (14% ± 3% vs. 2% ± 3% vs. 8% ± 3%), augmentation index normalized for heart rate (8% ± 3% vs. −3% ± 3% vs. 3% ± 3%), augmented pressure (5±1mm Hg vs. 1±1mm Hg vs. 3±1mm Hg), and pulse wave velocity (7.1±0.2 m/s vs. 6.7±0.2 m/s vs. 6.7±0.1 m/s) were substantially reduced at 60 and 180 minutes after the meal (all P < 0.05). CONCLUSIONS Taken together, our results suggest that a liquid mixed meal acutely decreases central hemodynamics and arterial stiffness in healthy adults, which may be a result of meal-related increases in insulin and/or visceral vasodilation.

blood pressure

sympathetic nerve activity

mixed meal

wave reflection

pulse wave velocity

hypertension

aortic pressure

Details

Title: Subtitle: Acute Effects of a Mixed Meal on Arterial Stiffness and Central Hemodynamics in Healthy Adults
Creators: Jennifer L Taylor - Department of Anesthesiology, Mayo Clinic
Timothy B Curry - Department of Anesthesiology, Mayo Clinic
Luke J Matzek - Department of Anesthesiology, Mayo Clinic
Michael J Joyner - Department of Anesthesiology, Mayo Clinic
Darren P Casey - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa
Resource Type: Journal article
Publication Details: American journal of hypertension, Vol.27(3), pp.331-337
Publisher: Oxford University Press; US
DOI: 10.1093/ajh/hpt211
PMID: 24242825
PMCID: PMC3915744
ISSN: 0895-7061
eISSN: 1879-1905
Language: English
Date published: 03/2014
Academic Unit: Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984047998402771

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