Acute Exercise Effects Predict Training Change in Cognition and Connectivity

Michelle W Voss; Timothy B Weng; Krithika Narayana-Kumanan; Rachel C Cole; Conner Wharff; Lauren Reist; Lyndsey Dubose; Gardar Sigurdsson; James A Mills; Jeffrey D Long; Vincent A Magnotta; Gary L Pierce

doi:10.1249/MSS.0000000000002115

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Acute Exercise Effects Predict Training Change in Cognition and Connectivity

Journal article

Open access

Peer reviewed

Acute Exercise Effects Predict Training Change in Cognition and Connectivity

Michelle W Voss, Timothy B Weng, Krithika Narayana-Kumanan, Rachel C Cole, Conner Wharff, Lauren Reist, Lyndsey Dubose, Gardar Sigurdsson, James A Mills, Jeffrey D Long, …

Medicine and science in sports and exercise, Vol.52(1), pp.131-140

01/2020

DOI: 10.1249/MSS.0000000000002115

PMCID: PMC7753185

PMID: 31385912

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https://www.ncbi.nlm.nih.gov/pmc/articles/7753185View

Open Access

Abstract

Previous studies report memory and functional connectivity of memory systems improve acutely after a single aerobic exercise session or with training, suggesting that the acute effects of aerobic exercise may reflect initial changes that adapt over time. In this trial, for the first time, we test the proof-of-concept of whether the acute and training effects of aerobic exercise on working memory and brain network connectivity are related in the same participants. Cognitively normal older participants (N = 34) were enrolled in a randomized clinical trial (NCT02453178). Participants completed fMRI resting state and a face working memory N-back task acutely after light- and moderate-intensity exercises and after a 12-wk aerobic training intervention. Functional connectivity did not change more after moderate-intensity training compared with light-intensity training. However, both training groups showed similar changes in cardiorespiratory fitness (CRF) (maximal exercise oxygen uptake, V˙O2peak), limiting group-level comparisons. Acute effects of moderate-intensity aerobic exercise on connections primarily in the default network predicted training enhancements in the same connections. Working memory also improved acutely, especially after moderate-intensity, and greater acute improvements predicted greater working memory improvement with training. Exercise effects on functional connectivity of right lateralized frontoparietal connections were related to both acute and training gains in working memory. Our data support the concept of acute aerobic exercise effects on functional brain systems and performance as an activity-evoked biomarker for exercise training benefits in the same outcomes. These findings may lead to new insights and methods for improving memory outcomes with aerobic exercise training.

Brain - diagnostic imaging

Cardiorespiratory Fitness

Humans

Middle Aged

Physical Conditioning, Human - physiology

Male

Memory, Short-Term - physiology

Brain - physiology

Proof of Concept Study

Magnetic Resonance Imaging

Aged, 80 and over

Cognition - physiology

Female

Aged

Exercise - physiology

Details

Title: Subtitle: Acute Exercise Effects Predict Training Change in Cognition and Connectivity
Creators: Michelle W Voss - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA
Timothy B Weng - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA
Krithika Narayana-Kumanan - Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA
Rachel C Cole - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA
Conner Wharff - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA
Lauren Reist - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA
Lyndsey Dubose - Department of Health and Human Physiology, University of Iowa, Iowa City, IA
Gardar Sigurdsson - Department of Internal Medicine, University of Iowa, Iowa City, IA
James A Mills - Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA
Jeffrey D Long
Vincent A Magnotta - Department of Radiology, University of Iowa, Iowa City, IA
Gary L Pierce - Department of Health and Human Physiology, University of Iowa, Iowa City, IA
Resource Type: Journal article
Publication Details: Medicine and science in sports and exercise, Vol.52(1), pp.131-140
DOI: 10.1249/MSS.0000000000002115
PMID: 31385912
PMCID: PMC7753185
NLM abbreviation: Med Sci Sports Exerc
ISSN: 0195-9131
eISSN: 1530-0315
Publisher: United States
Grant note: R01 AG055500 / NIA NIH HHS T32 GM108540 / NIGMS NIH HHS R21 AG048170 / NIA NIH HHS
Language: English
Date published: 01/2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Biostatistics; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984066135802771

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