Journal article
Acute Flare of Bullous Pemphigus With Pembrolizumab Used for Treatment of Metastatic Urothelial Cancer
Journal of immunotherapy (1997), Vol.41(1), pp.42-44
01/01/2018
DOI: 10.1097/CJI.0000000000000191
PMCID: PMC6339565
PMID: 29111983
Abstract
In the past decade, the resurgence of immunotherapy has changed the landscape of cancer therapy. Checkpoint inhibitors targeting cytotoxic T-lymphocyte antigen-4, programmed death-1 on lymphocytes, and programmed death ligand-1 on tumors cells are currently utilized in the management of several cancers. These agents are double-edged sword with the positive effect being robust antitumor response but on the other side they can throttle up the normal immunologic homeostasis in a negative way, leading to adverse autoimmune toxicities. These adverse toxicities are frequent if patients have active autoimmune disorders. Here, we report a rare case of quiescent bullous pemphigoid which flared after initiation of pembrolizumab, a programmed death ligand-1 inhibitor.
Details
- Title: Subtitle
- Acute Flare of Bullous Pemphigus With Pembrolizumab Used for Treatment of Metastatic Urothelial Cancer
- Creators
- Rohan Garje - Departments of Hematology and Oncology.Justin J. Chau - University of IowaJina Chung - University of IowaKarolyn Wanat - University of IowaYousef Zakharia - Departments of Hematology and Oncology.
- Resource Type
- Journal article
- Publication Details
- Journal of immunotherapy (1997), Vol.41(1), pp.42-44
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/CJI.0000000000000191
- PMID
- 29111983
- PMCID
- PMC6339565
- ISSN
- 1524-9557
- eISSN
- 1537-4513
- Number of pages
- 3
- Grant note
- P30 CA086862 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P30CA086862 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 01/01/2018
- Academic Unit
- Dermatology; Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359876302771
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