Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation

Michelle C. Starr; Louis Boohaker; Laurie C. Eldredge; Shina Menon; Russell Griffin; Dennis E. Mayock; Linzi Li; David Askenazi; Sangeeta Hingorani; Neonatal Kidney Collaborative

doi:10.1055/s-0039-3400311

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Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation

Journal article

Peer reviewed

Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation

Michelle C. Starr, Louis Boohaker, Laurie C. Eldredge, Shina Menon, Russell Griffin, Dennis E. Mayock, Linzi Li, David Askenazi, Sangeeta Hingorani and Neonatal Kidney Collaborative

American journal of perinatology, Vol.37(3), pp.341-348

02/2020

DOI: 10.1055/s-0039-3400311

PMCID: PMC7409513

PMID: 31777046

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https://www.ncbi.nlm.nih.gov/pmc/articles/7409513View

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Abstract

Abstract Objective This study aimed to evaluate the association between acute kidney injury (AKI) and bronchopulmonary dysplasia (BPD) in infants born <32 weeks of gestational age (GA). Study Design Present study is a secondary analysis of premature infants born at <32 weeks of GA in the Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) retrospective cohort ( n = 546). We stratified by gestational age and used logistic regression to determine association between AKI and moderate or severe BPD/mortality. Results Moderate or severe BPD occurred in 214 of 546 (39%) infants, while death occurred in 32 of 546 (6%); the composite of moderate or severe BPD/death occurred in 246 of 546 (45%). For infants born ≤29 weeks of gestation, the adjusted odds ratio (OR) of AKI and the primary outcome was 1.15 (95% confidence interval [CI] = 0.47–2.86; p = 0.76). Infants born between 29 and 32 weeks of gestation with AKI had four-fold higher odds of moderate or severe BPD/death that remained after controlling for multiple factors (adjusted OR = 4.21, 95% CI: 2.07–8.61; p < 0.001). Conclusion Neonates born between 29 and 32 weeks who develop AKI had a higher likelihood of moderate or severe BPD/death than those without AKI. Further studies are needed to validate our findings and evaluate mechanisms of multiorgan injury.

Original Article

Details

Title: Subtitle: Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation
Creators: Michelle C. Starr - Seattle Children's Hospital
Louis Boohaker - University of Alabama at Birmingham
Laurie C. Eldredge - University of Washington
Shina Menon - Seattle Children's Hospital
Russell Griffin - University of Alabama at Birmingham
Dennis E. Mayock - University of Washington
Linzi Li - University of Alabama at Birmingham
David Askenazi - University of Alabama at Birmingham
Sangeeta Hingorani - Seattle Children's Hospital
Neonatal Kidney Collaborative
Contributors: Tarah T Colaizy (Contributor) - University of Iowa, Neonatology
Jonathan M Klein (Contributor) - University of Iowa, Neonatology
Resource Type: Journal article
Publication Details: American journal of perinatology, Vol.37(3), pp.341-348
DOI: 10.1055/s-0039-3400311
PMID: 31777046
PMCID: PMC7409513
NLM abbreviation: Am J Perinatol
ISSN: 0735-1631
eISSN: 1098-8785
Publisher: Thieme Medical Publishers
Grant note: 100 Women Who Care Grant / Canberra Hospital Private Practice Fund U54TR001356 / University of Iowa Institute for Clinical and Translational Science The Pediatric and Infant Center for Acute Nephrology (PICAN) UL1TR001449 / Clinical and Translational Science Center at The University of New Mexico 100 Women Charitable Foundation Cincinnati Children's Hospital Center for Acute Care Nephrology
Language: English
Date published: 02/2020
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984354116902771

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