Journal article
Acute Pancreatitis in Individuals with Sickle Cell Disease: A Systematic Review
Journal of clinical medicine, Vol.13(16), 4712
08/11/2024
DOI: 10.3390/jcm13164712
PMCID: PMC11355684
PMID: 39200854
Abstract
Background/Objectives: Sickle cell disease (SCD) impacts about 100,000 people in the US. SCD increases the risk of cholelithiasis and microvascular ischemia, which could increase the risk of acute pancreatitis (AP). Abdominal pain is a common presenting symptom of AP and sickle cell vaso-occlusive crisis. The purpose of our systematic review is to estimate the prevalence and determine the severity of AP in individuals with SCD compared to the general population. Methods: Multiple electronic databases were searched. We included studies that included children and adults (population) and addressed the association of SCD (exposure) with AP (outcome) compared to the same population without SCD (control). Two authors screened titles and abstracts independently, and data were abstracted in duplication from included studies. We registered this protocol in PROSPERO-CRD42023422397. Results: Out of 296 studies screened from multiple electronic databases, we identified 33 studies. These studies included 17 case reports, one case series, and 15 retrospective cohort studies, and 18 studies included children. Eight of the AP case reports were in patients with HbSS genotype, two with sickle beta thalassemia, and one with HbSoArab, and in six case reports, a genotype was not specified. Complications were reported in 11 cases—respiratory complication (in at least four cases), splenic complications (three cases), pancreatic pseudocyst (two cases) and death from AP (one case). Of the four AP cases in the case series, three had HbSS genotype, and two cases had complications and severe pancreatitis. AP prevalence in SCD was estimated to be 2% and 7% in two retrospective studies, but they lacked a comparison group. In retrospective studies that evaluated the etiology of AP in children, biliary disease caused mostly by SCD was present in approximately 12% and 34%, respectively. Conclusions: Data on the prevalence of AP in individuals with SCD are limited. Prospectively designed studies aiming to proactively evaluate AP in individuals with SCD who present with abdominal pain are needed to improve timely diagnosis of AP in SCD and outcomes.
Details
- Title: Subtitle
- Acute Pancreatitis in Individuals with Sickle Cell Disease: A Systematic Review
- Creators
- Chinenye R. Dike - University of Alabama at BirminghamAdefunke DadeMatthews - Auburn UniversityOluwagbemiga DadeMatthews - Louisiana State UniversityMaisam Abu-El-Haija - University of CincinnatiJeffrey Lebensburger - University of Alabama at BirminghamAbigail Smith - SUNY Upstate Medical UniversityAamer Imdad - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of clinical medicine, Vol.13(16), 4712
- Publisher
- MDPI
- DOI
- 10.3390/jcm13164712
- PMID
- 39200854
- PMCID
- PMC11355684
- ISSN
- 2077-0383
- eISSN
- 2077-0383
- Grant note
This research was funded by NHLBI NIH K23HL173704 and the APC was funded by NHLBI NIH K23HL173704 and Department of Pediatrics, University of Alabama at Birmingham.
- Language
- English
- Date published
- 08/11/2024
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984696805002771
Metrics
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