Journal article
Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection
Cell reports (Cambridge), Vol.30(12), pp.4041-4051.e4
03/24/2020
DOI: 10.1016/j.celrep.2020.02.104
PMCID: PMC7172281
PMID: 32209467
Abstract
During the 2013-2016 Ebola virus (EBOV) epidemic, a significant number of patients admitted to Ebola treatment units were co-infected with Plasmodium falciparum, a predominant agent of malaria. However, there is no consensus on how malaria impacts EBOV infection. The effect of acute Plasmodium infection on EBOV challenge was investigated using mouse-adapted EBOV and a biosafety level 2 (BSL-2) model virus. We demonstrate that acute Plasmodium infection protects from lethal viral challenge, dependent upon interferon gamma (IFN-gamma) elicited as a result of parasite infection. Plasmodium-infected mice lacking the IFN-gamma receptor are not protected. Ex vivo incubation of naive human or mouse macrophages with sera from acutely parasitemic rodents or macaques programs a proinflammatory phenotype dependent on IFN-gamma and renders cells resistant to EBOV infection. We conclude that acute Plasmodium infection can safeguard against EBOV by the production of protective IFN-gamma. These findings have implications for anti-malaria therapies administered during episodic EBOV outbreaks in Africa.
Details
- Title: Subtitle
- Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection
- Creators
- Kai J. Rogers - University of IowaOlena Shtanko - Texas Biomedical Research InstituteRahul Vijay - University of IowaLaura N. Mallinger - University of IowaChester J. Joyner - Emory UniversityMary R. Galinski - Emory UniversityNoah S. Butler - University of IowaWendy Maury - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.30(12), pp.4041-4051.e4
- DOI
- 10.1016/j.celrep.2020.02.104
- PMID
- 32209467
- PMCID
- PMC7172281
- NLM abbreviation
- Cell Rep
- ISSN
- 2211-1247
- eISSN
- 2211-1247
- Publisher
- Elsevier
- Number of pages
- 15
- Grant note
- HHSN272201200031C / NIH/NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) AI125446; AI127481; T32 GM007337; T32 GM 067795; UL1TR002537 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA OD P51OD011132 / NIH Office of Research Infrastructure Programs; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 03/24/2020
- Academic Unit
- Molecular Physiology and Biophysics; Microbiology and Immunology
- Record Identifier
- 9984297425102771
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