Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents

Ahmed A Ismail; Olfat Hendy; Gaafar Abdel Rasoul; James R Olson; Matthew R Bonner; Diane S Rohlman

doi:10.3390/toxics9060137

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Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents

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Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents

Ahmed A Ismail, Olfat Hendy, Gaafar Abdel Rasoul, James R Olson, Matthew R Bonner and Diane S Rohlman

Toxics (Basel), Vol.9(6), p.137

06/01/2021

DOI: 10.3390/toxics9060137

PMCID: PMC8230541

PMID: 34200920

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Abstract

Background: There is a paucity of research that tracks changes in liver and kidney function among pesticide applicators. The aim of the current study was to investigate the role of repeated seasonal exposure to the organophosphorus pesticide, chlorpyrifos, on serum measures of liver and kidney function. Methods: Pesticide exposure was assessed by measuring the urinary concentrations of 3,5,6-trichloro-2 pyridinol (TCPy), a specific biomarker for chlorpyrifos. Chlorpyrifos exposure and 8 serum markers of liver and kidney function were measured at 15 timepoints over 3 years prior to, during, and following the end of seasonal pesticide application among adolescent applicators and non-applicators from 4 field stations in Menoufia, Egypt. Results: Urinary TCPy levels showed increases during the application cycles and recovery at the end of each application season. Altered serum markers of liver and kidney function were associated with chlorpyrifos exposure, with some markers recovering 3 months after the end of exposure each year, while other measures demonstrated progressive increase up to 300% the baseline levels at the end of 3 years. Conclusion: The study demonstrated that frequent assessment of liver and kidney function is a sound practice to evaluate cellular injury following chronic repeated occupational and environmental exposure to chlorpyrifos.

adolescents

chlorpyrifos

cholinesterase activity

kidney function

liver function

organophosphorus

Details

Title: Subtitle: Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents
Creators: Ahmed A Ismail - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA; Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin Elkom 32511, Egypt; Kansas Department of Health and Environment, State of Kansas, Topeka, KS 66612, USA Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt; Department of Epidemiology and Environmental Health, State University of New York, Buffalo, NY 14260, USA; (J.R.O.); (M.R.B.) Department of Pharmacology and Toxicology, State University of New York, Buffalo, NY 14260, USA
Olfat Hendy - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA; Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin Elkom 32511, Egypt; Kansas Department of Health and Environment, State of Kansas, Topeka, KS 66612, USA Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt; Department of Epidemiology and Environmental Health, State University of New York, Buffalo, NY 14260, USA; (J.R.O.); (M.R.B.) Department of Pharmacology and Toxicology, State University of New York, Buffalo, NY 14260, USA
Gaafar Abdel Rasoul - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA; Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin Elkom 32511, Egypt; Kansas Department of Health and Environment, State of Kansas, Topeka, KS 66612, USA Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt; Department of Epidemiology and Environmental Health, State University of New York, Buffalo, NY 14260, USA; (J.R.O.); (M.R.B.) Department of Pharmacology and Toxicology, State University of New York, Buffalo, NY 14260, USA
James R Olson - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA; Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin Elkom 32511, Egypt; Kansas Department of Health and Environment, State of Kansas, Topeka, KS 66612, USA Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt; Department of Epidemiology and Environmental Health, State University of New York, Buffalo, NY 14260, USA; (J.R.O.); (M.R.B.) Department of Pharmacology and Toxicology, State University of New York, Buffalo, NY 14260, USA
Matthew R Bonner - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA; Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin Elkom 32511, Egypt; Kansas Department of Health and Environment, State of Kansas, Topeka, KS 66612, USA Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt; Department of Epidemiology and Environmental Health, State University of New York, Buffalo, NY 14260, USA; (J.R.O.); (M.R.B.) Department of Pharmacology and Toxicology, State University of New York, Buffalo, NY 14260, USA
Diane S Rohlman - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA; Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin Elkom 32511, Egypt; Kansas Department of Health and Environment, State of Kansas, Topeka, KS 66612, USA Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt; Department of Epidemiology and Environmental Health, State University of New York, Buffalo, NY 14260, USA; (J.R.O.); (M.R.B.) Department of Pharmacology and Toxicology, State University of New York, Buffalo, NY 14260, USA
Resource Type: Journal article
Publication Details: Toxics (Basel), Vol.9(6), p.137
DOI: 10.3390/toxics9060137
PMID: 34200920
PMCID: PMC8230541
NLM abbreviation: Toxics
ISSN: 2305-6304
eISSN: 2305-6304
Publisher: MDPI
Grant note: DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: ES022163
Language: English
Date published: 06/01/2021
Academic Unit: Occupational and Environmental Health; International Programs; Injury Prevention Research Center
Record Identifier: 9984214799002771

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