Journal article
Acute and chronic effects of hypoxia on the developing hippocampus
Annals of neurology, Vol.41(2), pp.187-199
02/1997
DOI: 10.1002/ana.410410210
PMID: 9029068
Abstract
Perinatal hypoxia i associated with both seizures arising acutely and the subsequent development of temporal lobe epilepsy (as determined retrospectively). We terefore attempted to identify acute and chronic morphological and/or electrophysiological hippocampal pathologies assiciated with experimentally induced hypoxia in immature rats. Pups were exposed to 15 minutes of hypoxia on 3 successive days (starting on postnatal dya 8; P8), or to 60 minutes of hypoxia on P10 with either one or multiple hupoxia-induced seizures. For animals experiencing multiple seizures, flurothyl seizure threshold was significantly lower than that of controls at 60 to 80 days, but not at 10 days, after hypoxia. Acutely, there was a treatment-related increase in the number and the density of pyknotic dentate and hilar neurons, in particular in animals experiencing multiple seizures. However, 60 to 80 days after the multiple-sezure protocol, the number of dentate and hilar neurons did not differ between expermental and control animals at any time point. These results indicate that early postnatal hupoxia and hypoxia-induced seizure episodes decrease seizure threshold in the adult but produce minimal acute or chronic morphological or functional chages in the hippocampus.
Details
- Title: Subtitle
- Acute and chronic effects of hypoxia on the developing hippocampus
- Creators
- James Owens Jr - University of WashingtonCarol A. Robbins - University of WashingtonH. Jurgen Wenzel - University of WashingtonPhilip A. Schwartzkroin - University of Washington
- Resource Type
- Journal article
- Publication Details
- Annals of neurology, Vol.41(2), pp.187-199
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/ana.410410210
- PMID
- 9029068
- ISSN
- 0364-5134
- eISSN
- 1531-8249
- Number of pages
- 13
- Language
- English
- Date published
- 02/1997
- Academic Unit
- Stead Family Department of Pediatrics; Neurology (Pediatrics)
- Record Identifier
- 9984701642602771
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