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Acute cardiac injury in adult hospitalized COVID-19 patients in Zhuhai, China
Journal article   Open access

Acute cardiac injury in adult hospitalized COVID-19 patients in Zhuhai, China

Lizi Jin, Wenyi Tang, Lizheng Song, Liyun Luo, Zhijuan Zhou, Xiuwu Fan, Jinyou Zhang, Niujian Wu, Kan Liu and Jian Chen
Cardiovascular diagnosis and therapy, Vol.10(5), pp.1303-1312
10/01/2020
DOI: 10.21037/cdt-20-607
PMCID: PMC7666934
PMID: 33224754
url
https://doi.org/10.21037/cdt-20-607View
Published (Version of record) Open Access

Abstract

Background: Coronavirus disease 2019 (COVID-19) has already became a public health emergency of international concern. COVID-19 related cardiac injury remains largely unclear. Methods: retrospectively analyzed demographic, clinical, laboratory and cardiovascular imaging data of all consecutively admitted adult COVID-19 patients in Zhuhai, China from January 17th, 2020 to February 18th, 2020. Results: A total of 93 patients were included in the study. Acute cardiac injury was found in 9 (9.7%) COVID-19 patients with median level of hypersensitive cardiac troponin I (hs-cTnI) to be 0.085 mu g/L (IQR 0.027-0.560 mu g/L). Compared with patients without cardiac injury, the median age of patients with cardiac injury was significantly older (65.0 vs. 44.0, P<0.05), hypertension was significantly more common (44.4% vs. 14.3%, P<0.05), and the proportion of severe-critical cases were greater (77.8% vs. 17.9%, P<0.05). Patients with cardiac injury were more likely have elevation of N-terminal proBNP (NT-proBNP) in comparison (66.7% vs. 10.0%, P<0.05). There was no significant difference in echocardiographic parameters between patients with and without cardiac injury. Multivariable logistic regression analysis indicated that older age (OR: 1.093, 95% CI: 1.011-1.182) and increased NT-proBNP (OR: 10.979, 95% CI: 2.024-59.555) were independent risk factors for cardiac injury. Cardiac magnetic resonance (CMR) imaging performed on three patients at around one month after they underwent significant hs-cTnI elevation showed that they had underlying cardiovascular comorbidities. Conclusions: Acute cardiac injury was seen in the minority of hospitalized COVID-19 patients in Zhuhai, China. Older age and increased NT-proBNP were associated with acute cardiac injury.
 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Life Sciences & Biomedicine Science & Technology

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