Journal article
Acute cor pulmonale due to pulmonary tumour thrombotic microangiopathy from renal cell carcinoma
BMJ case reports, Vol.2017, p.bcr-2017-219730
06/28/2017
DOI: 10.1136/bcr-2017-219730
PMCID: PMC5534775
PMID: 28659364
Abstract
We report the case of a previously healthy man who presented with subacute dyspnoea after a long drive. He developed hypoxic respiratory failure, thought secondary to a massive pulmonary embolism and was treated with tissue plasminogen activator but died in the hospital despite aggressive medical measures. Autopsy revealed pulmonary tumour thrombotic microangiopathy (PTTM) from papillary renal cell carcinoma. PTTM is a rare clinicopathological syndrome that clinically results in symptoms of dyspnoea and right heart failure. Pathologically, a localised paraneoplastic process evolves from tumour microemboli in the pulmonary arterioles, resulting in fibrocellular proliferation and narrowing of the vessels, causing subacute right heart failure. To our knowledge, this is the first case of PTTM due to papillary renal cell carcinoma.
Details
- Title: Subtitle
- Acute cor pulmonale due to pulmonary tumour thrombotic microangiopathy from renal cell carcinoma
- Creators
- Maria Story - Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USASook Kyung Kwon - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USARobert Robinson - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USASpyridon Fortis - Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- BMJ case reports, Vol.2017, p.bcr-2017-219730
- DOI
- 10.1136/bcr-2017-219730
- PMID
- 28659364
- PMCID
- PMC5534775
- ISSN
- 1757-790X
- eISSN
- 1757-790X
- Language
- English
- Electronic publication date
- 06/28/2017
- Academic Unit
- Physician Assistant Studies; Pulmonary, Critical Care, and Occupational Medicine; Oral Pathology, Radiology and Medicine; Pathology; Internal Medicine
- Record Identifier
- 9984047679702771
Metrics
22 Record Views